Apolipoprotein L (Apo L) is found in high-density lipoprotein complexes that plays a central role in cholesterol transport. The cholesterol content of membranes is important in cellular processes such as modulating gene transcription and signal transduction both in the adult brain and during neurodevelopment. There are six apo L genes located in close proximity to each other on chromosome 22q12 in humans. 22q12 is a confirmed high-susceptibility locus for schizophrenia and close to the region associated with velocardiofacial syndrome that includes symptoms of schizophrenia.[1]
^Arai H, Mimmack ML, Ryan M, Baba H, Navarro-ruiz J, Iritani S, Faull RL, Mckenna PJ, Jones PB, Starkey M, Emson PC, Bahn S (2002). "Gene expression analysis in schizophrenia: reproducible up-regulation of several members of the apolipoprotein L family located in a high-susceptibility locus for schizophrenia on chromosome 22". Proc. Natl. Acad. Sci. U.S.A. 99 (7): 4680–4685. Bibcode:2002PNAS...99.4680M. doi:10.1073/pnas.032069099. PMC123707. PMID 11930015.
This article incorporates text from the public domain Pfam and InterPro: IPR008405
January 01, 1970
apolipoprotein, found, high, density, lipoprotein, complexes, that, plays, central, role, cholesterol, transport, cholesterol, content, membranes, important, cellular, processes, such, modulating, gene, transcription, signal, transduction, both, adult, brain, . Apolipoprotein L Apo L is found in high density lipoprotein complexes that plays a central role in cholesterol transport The cholesterol content of membranes is important in cellular processes such as modulating gene transcription and signal transduction both in the adult brain and during neurodevelopment There are six apo L genes located in close proximity to each other on chromosome 22q12 in humans 22q12 is a confirmed high susceptibility locus for schizophrenia and close to the region associated with velocardiofacial syndrome that includes symptoms of schizophrenia 1 Apolipoprotein LIdentifiersSymbolApoLPfamPF05461InterProIPR008405Available protein structures Pfam structures ECOD PDBRCSB PDB PDBe PDBjPDBsumstructure summaryHuman proteins containing this domain editAPOL1 APOL2 APOL3 APOL4 APOL5 APOL6 APOLD1 References edit Arai H Mimmack ML Ryan M Baba H Navarro ruiz J Iritani S Faull RL Mckenna PJ Jones PB Starkey M Emson PC Bahn S 2002 Gene expression analysis in schizophrenia reproducible up regulation of several members of the apolipoprotein L family located in a high susceptibility locus for schizophrenia on chromosome 22 Proc Natl Acad Sci U S A 99 7 4680 4685 Bibcode 2002PNAS 99 4680M doi 10 1073 pnas 032069099 PMC 123707 PMID 11930015 This article incorporates text from the public domain Pfam and InterPro IPR008405 Retrieved from https en wikipedia org w index php title Apolipoprotein L amp oldid 1059873660, wikipedia, wiki, book, books, library,
