Antiprion drugs are drugs that work against prions. The discovery of antiprion drugs is a priority because prion diseases are untreatable and fatal.[1] Therefore, it is a therapeutic priority to find effective anti-prion drugs.[citation needed]
The disease progression in prion diseases is probably due to the conformational change of the prion protein (PrP). PrP changes from alpha-helical conformation to a disease-associated, mainly beta-sheeted scrapie isoform (PrPSc), which forms amyloid aggregates. The drugs that contain N′-benzylidene-benzohydrazide core structure are likely to slow down this progression.[2] Drugs that target PrPC, the normal prion isoform, are also hypothesized to delay the progression of prion diseases.[3]
Referencesedit
^Mercer, Robert CC; Harris, David A (1 February 2019). "Identification of anti-prion drugs and targets using toxicity-based assays". Current Opinion in Pharmacology. 44: 20–27. doi:10.1016/j.coph.2018.12.005. ISSN 1471-4892. PMC6561806. PMID 30684854.
^Bertsch, U.; Winklhofer, K. F.; Hirschberger, T.; Bieschke, J.; Weber, P.; Hartl, F. U.; Tavan, P.; Tatzelt, J.; Kretzschmar, H. A.; Giese, A. (26 May 2005). "Systematic Identification of Antiprion Drugs by High-Throughput Screening Based on Scanning for Intensely Fluorescent Targets". Journal of Virology. 79 (12): 7785–7791. doi:10.1128/JVI.79.12.7785-7791.2005. PMC1143673. PMID 15919931.
^Le Bras, Alexandra (April 2019). "A new drug to treat prion diseases". Lab Animal. 48 (4): 116. doi:10.1038/s41684-019-0273-2. ISSN 1548-4475.
December 07, 2023
antiprion, drug, drugs, that, work, against, prions, discovery, antiprion, drugs, priority, because, prion, diseases, untreatable, fatal, therefore, therapeutic, priority, find, effective, anti, prion, drugs, citation, needed, contents, mechanism, action, refe. Antiprion drugs are drugs that work against prions The discovery of antiprion drugs is a priority because prion diseases are untreatable and fatal 1 Therefore it is a therapeutic priority to find effective anti prion drugs citation needed Contents 1 Mechanism of action 2 ReferencesMechanism of action editThe disease progression in prion diseases is probably due to the conformational change of the prion protein PrP PrP changes from alpha helical conformation to a disease associated mainly beta sheeted scrapie isoform PrPSc which forms amyloid aggregates The drugs that contain N benzylidene benzohydrazide core structure are likely to slow down this progression 2 Drugs that target PrPC the normal prion isoform are also hypothesized to delay the progression of prion diseases 3 References edit Mercer Robert CC Harris David A 1 February 2019 Identification of anti prion drugs and targets using toxicity based assays Current Opinion in Pharmacology 44 20 27 doi 10 1016 j coph 2018 12 005 ISSN 1471 4892 PMC 6561806 PMID 30684854 Bertsch U Winklhofer K F Hirschberger T Bieschke J Weber P Hartl F U Tavan P Tatzelt J Kretzschmar H A Giese A 26 May 2005 Systematic Identification of Antiprion Drugs by High Throughput Screening Based on Scanning for Intensely Fluorescent Targets Journal of Virology 79 12 7785 7791 doi 10 1128 JVI 79 12 7785 7791 2005 PMC 1143673 PMID 15919931 Le Bras Alexandra April 2019 A new drug to treat prion diseases Lab Animal 48 4 116 doi 10 1038 s41684 019 0273 2 ISSN 1548 4475 Retrieved from https en wikipedia org w index php title Antiprion drug amp oldid 1136909620, wikipedia, wiki, book, books, library,
