β2-glycoprotein I has been identified as apolipoprotein H and is required for the recognition of ACA in autoimmune disease.[8] Only a subset of autoimmune anti-cardiolipin antibodies bind Apo-H, these anti-apolipoprotein antibodies are associated with increased thrombosis.
Referencesedit
^ abTringali GR, Julian AJ, Halbert WM (1969). "Effect of 2-mercaptoethanol treatment on anticardiolipin reactivity in sera from syphilitics and false positive reactors". The British Journal of Venereal Diseases. 45 (3): 202–4. doi:10.1136/sti.45.3.202. PMC1048465. PMID 5346419.
^Hull RG, Harris EN, Gharavi AE, et al. (1984). "Anticardiolipin antibodies: occurrence in Behçet's syndrome". Ann. Rheum. Dis. 43 (5): 746–748. doi:10.1136/ard.43.5.746. PMC1001520. PMID 6497467.
^Petri M, Golbus M, Anderson R, Whiting-O'Keefe Q, Corash L, Hellmann D (1987). "Antinuclear antibody, lupus anticoagulant, and anticardiolipin antibody in women with idiopathic habitual abortion. A controlled, prospective study of forty-four women". Arthritis Rheum. 30 (6): 601–606. doi:10.1002/art.1780300601. PMID 3111489.
^Harris EN, Gharavi AE, Boey ML, et al. (1983). "Anticardiolipin antibodies: detection by radioimmunoassay and association with thrombosis in systemic lupus erythematosus". Lancet. 2 (8361): 1211–1214. doi:10.1016/S0140-6736(83)91267-9. PMID 6139567. S2CID 36643723.
^Harris EN, Gharavi AE, Loizou S, et al. (1985). "Crossreactivity of antiphospholipid antibodies". Journal of Clinical & Laboratory Immunology. 16 (1): 1–6. PMID 3981615.
^Keane A, Woods R, Dowding V, Roden D, Barry C (1987). "Anticardiolipin antibodies in rheumatoid arthritis". Br. J. Rheumatol. 26 (5): 346–350. doi:10.1093/rheumatology/26.5.346. PMID 3664159.
^Malia RG, Greaves M, Rowlands LM, et al. (1988). "Anticardiolipin antibodies in systemic sclerosis: immunological and clinical associations". Clin. Exp. Immunol. 73 (3): 456–60. PMC1541778. PMID 2974767.
^McNeil HP, Simpson RJ, Chesterman CN, Krilis SA (1990). "Anti-phospholipid antibodies are directed against a complex antigen that includes a lipid-binding inhibitor of coagulation: beta 2-glycoprotein I (apolipoprotein H)". Proc. Natl. Acad. Sci. U.S.A. 87 (11): 4120–4124. Bibcode:1990PNAS...87.4120M. doi:10.1073/pnas.87.11.4120. PMC54059. PMID 2349221.
April 12, 2024
anti, cardiolipin, antibodies, antibodies, often, directed, against, cardiolipin, found, several, diseases, including, syphilis, antiphospholipid, syndrome, livedoid, vasculitis, vertebrobasilar, insufficiency, behçet, syndrome, idiopathic, spontaneous, aborti. Anti cardiolipin antibodies ACA are antibodies often directed against cardiolipin and found in several diseases including syphilis 1 antiphospholipid syndrome livedoid vasculitis vertebrobasilar insufficiency Behcet s syndrome 2 idiopathic spontaneous abortion 3 and systemic lupus erythematosus SLE 4 They are a form of anti mitochondrial antibody In SLE anti DNA antibodies and anti cardiolipin antibodies may be present individually or together the two types of antibodies act independently 5 This is in contrast to rheumatoid arthritis 6 with systemic sclerosis scleroderma 7 because anti cardiolipin antibodies are present in both conditions and therefore may tie the two conditions together Schematic representation of antibodyAnti cardiolipin antibodies can be classified in two ways As IgM IgG or IgA As b2 glycoprotein dependent or independent In autoimmune disease ACA are beta 2 glycoprotein dependent In syphilis ACA 1 are beta 2 glycoprotein independent and can be assayed using the Venereal Disease Research Laboratory testApolipoprotein H involvement editb2 glycoprotein I has been identified as apolipoprotein H and is required for the recognition of ACA in autoimmune disease 8 Only a subset of autoimmune anti cardiolipin antibodies bind Apo H these anti apolipoprotein antibodies are associated with increased thrombosis References edit a b Tringali GR Julian AJ Halbert WM 1969 Effect of 2 mercaptoethanol treatment on anticardiolipin reactivity in sera from syphilitics and false positive reactors The British Journal of Venereal Diseases 45 3 202 4 doi 10 1136 sti 45 3 202 PMC 1048465 PMID 5346419 Hull RG Harris EN Gharavi AE et al 1984 Anticardiolipin antibodies occurrence in Behcet s syndrome Ann Rheum Dis 43 5 746 748 doi 10 1136 ard 43 5 746 PMC 1001520 PMID 6497467 Petri M Golbus M Anderson R Whiting O Keefe Q Corash L Hellmann D 1987 Antinuclear antibody lupus anticoagulant and anticardiolipin antibody in women with idiopathic habitual abortion A controlled prospective study of forty four women Arthritis Rheum 30 6 601 606 doi 10 1002 art 1780300601 PMID 3111489 Harris EN Gharavi AE Boey ML et al 1983 Anticardiolipin antibodies detection by radioimmunoassay and association with thrombosis in systemic lupus erythematosus Lancet 2 8361 1211 1214 doi 10 1016 S0140 6736 83 91267 9 PMID 6139567 S2CID 36643723 Harris EN Gharavi AE Loizou S et al 1985 Crossreactivity of antiphospholipid antibodies Journal of Clinical amp Laboratory Immunology 16 1 1 6 PMID 3981615 Keane A Woods R Dowding V Roden D Barry C 1987 Anticardiolipin antibodies in rheumatoid arthritis Br J Rheumatol 26 5 346 350 doi 10 1093 rheumatology 26 5 346 PMID 3664159 Malia RG Greaves M Rowlands LM et al 1988 Anticardiolipin antibodies in systemic sclerosis immunological and clinical associations Clin Exp Immunol 73 3 456 60 PMC 1541778 PMID 2974767 McNeil HP Simpson RJ Chesterman CN Krilis SA 1990 Anti phospholipid antibodies are directed against a complex antigen that includes a lipid binding inhibitor of coagulation beta 2 glycoprotein I apolipoprotein H Proc Natl Acad Sci U S A 87 11 4120 4124 Bibcode 1990PNAS 87 4120M doi 10 1073 pnas 87 11 4120 PMC 54059 PMID 2349221 Retrieved from https en wikipedia org w index php title Anti cardiolipin antibodies amp oldid 1169906252, wikipedia, wiki, book, books, library,
