Ann Silver (23 November 1929 – 10 March 2023) was a British physiologist, known for her pioneering work on the neurotransmitter acetylcholine.[1] She wrote a seminal text on the Biology of cholinesterases[2] in 1974 and helped to lay the foundations of the cholinergic hypothesis by mapping cholinergic systems and helping to emphasise the importance of these pathways in brain areas central to cognitive and memory functions, leading to the use of cholinesterase inhibitors in the treatment of Alzheimer's disease.[3]
Ann Silver was born at a British hospital in India where her father was serving in the Indian army. Although a baptismal certificate states that she was "said to be born" on 23 November 1929, no actual birth certificate was issued.[4] Her father was born in Grenada, then part of the British West Indies, where his Scottish father was a Church of Scotland minister. The family returned to Britain in 1930 and settled in Suffolk. She has an older brother, Ian A. Silver, who studied zoology at Cambridge, where he then lectured on veterinary anatomy. He is now an emeritus professor of Comparative Pathology at Bristol University.
Silver died on 10 March 2023, at the age of 93.[5][6]
Educationedit
Babraham Institute buildings
Silver was educated at the University of Edinburgh, where she studied zoology, physiology and pharmacology graduating with a BSc (Hons) in 1954. In 1961 she was awarded a PhD[7] in physiology, concerning the transport of choline acetyltransferase in nerves. Her PhD was undertaken as an external student since she was based in Cambridge at that time, carrying out research work for the Agricultural Research Council Institute of Animal Physiology at Babraham (later Babraham Institute).[3]
Careeredit
Catherine Hebb, who had first stimulated Silver's interest in cholinesterases while teaching at the University of Edinburgh, invited Silver to join her when she moved to The Agricultural Research Council Institute of Animal Physiology at Babraham. Silver's initial research was on organophosphorous compounds and their anti-cholinesterase effects. The institute was to remain Ann's employer for most of her career, where she continued to work with Catherine Hebb, co-authoring several papers on their research on the acetylcholine system.[8] While there, Silver worked on the acetylcholine system, mapping the enzymes, choline acetyltransferase (ChAT) and acetylcholinesterase (AchE) and investigating the nerve transport mechanism. She worked with many other eminent scientists at Babraham, a number of whom had also come from or studied at the University of Edinburgh. These included the director Sir John Gaddum, pharmacologist and neurochemist, Marthe Vogt, who had previously lectured in pharmacology and neuro-physiologist Krešimir Krnjević, who had also gained a PhD at the university. After many years in the lab, Silver eventually moved into the role of Information Officer, when a rise in anti-vivisection activity prompted a need for better public relations and awareness. Previous experience of working with the Physiological Society[4] on what would or would not be licensed, made her a suitable candidate for this role. Silver then became ethical editor on the Journal of Physiology, where several of her own research articles were published, ensuring that experiments in any published papers had been conducted humanely.[1]
Referencesedit
^ abRichardson, Thomas (2017-06-26). "Silver, Ann: transcript of a video interview (07- and 08-Sep-2007)".
^Silver, Ann (1974). The biology of cholinesterases. Amsterdam; New York: North-Holland Pub. Co. ; American Elsevier Pub. Co. ISBN978-0-444-10652-0. OCLC 1302832.
^ ab"Dr Ann Silver". histmodbiomed.org. Retrieved 2019-03-08.
^ abWalters, Dafydd (January 2015). "An interview with Ann Silver" (PDF). Physiological Society site. Retrieved 8 March 2019.
^"Dr. Ann Silver". Funeral Notices. 22 March 2023. Retrieved 5 January 2024.
^"Obituary: Ann Silver (1929–2023)". The Physiological Society. Retrieved 5 January 2024.
^Silver, A. (1961). Some aspects of nerve degeneration with special reference to changes in enzyme composition (Thesis). hdl:1842/16305.
^"Catherine Hebb's research while affiliated with Babraham Institute and other places". ResearchGate. Retrieved 2019-03-14.
January 01, 1970
silver, november, 1929, march, 2023, british, physiologist, known, pioneering, work, neurotransmitter, acetylcholine, wrote, seminal, text, biology, cholinesterases, 1974, helped, foundations, cholinergic, hypothesis, mapping, cholinergic, systems, helping, em. Ann Silver 23 November 1929 10 March 2023 was a British physiologist known for her pioneering work on the neurotransmitter acetylcholine 1 She wrote a seminal text on the Biology of cholinesterases 2 in 1974 and helped to lay the foundations of the cholinergic hypothesis by mapping cholinergic systems and helping to emphasise the importance of these pathways in brain areas central to cognitive and memory functions leading to the use of cholinesterase inhibitors in the treatment of Alzheimer s disease 3 Ann SilverBorn 1929 11 23 23 November 1929British IndiaDied10 March 2023 2023 03 10 aged 93 NationalityBritishEducationUniversity of EdinburghKnown forCholinesterases research Acetylcholine Contents 1 Background 2 Education 3 Career 4 ReferencesBackground editAnn Silver was born at a British hospital in India where her father was serving in the Indian army Although a baptismal certificate states that she was said to be born on 23 November 1929 no actual birth certificate was issued 4 Her father was born in Grenada then part of the British West Indies where his Scottish father was a Church of Scotland minister The family returned to Britain in 1930 and settled in Suffolk She has an older brother Ian A Silver who studied zoology at Cambridge where he then lectured on veterinary anatomy He is now an emeritus professor of Comparative Pathology at Bristol University Silver died on 10 March 2023 at the age of 93 5 6 Education edit nbsp Babraham Institute buildings Silver was educated at the University of Edinburgh where she studied zoology physiology and pharmacology graduating with a BSc Hons in 1954 In 1961 she was awarded a PhD 7 in physiology concerning the transport of choline acetyltransferase in nerves Her PhD was undertaken as an external student since she was based in Cambridge at that time carrying out research work for the Agricultural Research Council Institute of Animal Physiology at Babraham later Babraham Institute 3 Career editCatherine Hebb who had first stimulated Silver s interest in cholinesterases while teaching at the University of Edinburgh invited Silver to join her when she moved to The Agricultural Research Council Institute of Animal Physiology at Babraham Silver s initial research was on organophosphorous compounds and their anti cholinesterase effects The institute was to remain Ann s employer for most of her career where she continued to work with Catherine Hebb co authoring several papers on their research on the acetylcholine system 8 While there Silver worked on the acetylcholine system mapping the enzymes choline acetyltransferase ChAT and acetylcholinesterase AchE and investigating the nerve transport mechanism She worked with many other eminent scientists at Babraham a number of whom had also come from or studied at the University of Edinburgh These included the director Sir John Gaddum pharmacologist and neurochemist Marthe Vogt who had previously lectured in pharmacology and neuro physiologist Kresimir Krnjevic who had also gained a PhD at the university After many years in the lab Silver eventually moved into the role of Information Officer when a rise in anti vivisection activity prompted a need for better public relations and awareness Previous experience of working with the Physiological Society 4 on what would or would not be licensed made her a suitable candidate for this role Silver then became ethical editor on the Journal of Physiology where several of her own research articles were published ensuring that experiments in any published papers had been conducted humanely 1 References edit a b Richardson Thomas 2017 06 26 Silver Ann transcript of a video interview 07 and 08 Sep 2007 Silver Ann 1974 The biology of cholinesterases Amsterdam New York North Holland Pub Co American Elsevier Pub Co ISBN 978 0 444 10652 0 OCLC 1302832 a b Dr Ann Silver histmodbiomed org Retrieved 2019 03 08 a b Walters Dafydd January 2015 An interview with Ann Silver PDF Physiological Society site Retrieved 8 March 2019 Dr Ann Silver Funeral Notices 22 March 2023 Retrieved 5 January 2024 Obituary Ann Silver 1929 2023 The Physiological Society Retrieved 5 January 2024 Silver A 1961 Some aspects of nerve degeneration with special reference to changes in enzyme composition Thesis hdl 1842 16305 Catherine Hebb s research while affiliated with Babraham Institute and other places ResearchGate Retrieved 2019 03 14 Retrieved from https en wikipedia org w index php title Ann Silver amp oldid 1203075185, wikipedia, wiki, book, books, library,
