Adrian John Brown, FRS (27 April 1852 – 2 July 1919[1]) was a British Professor of Malting and Brewing at the University of Birmingham and a pioneer in the study of enzyme kinetics.
He was born at Burton-on-Trent, Staffordshire to Edwin Brown, a bank manager in the town. His elder brother was Horace Tabberer Brown. He attended the local grammar school and then went up to study chemistry at the Royal College of Science in London. He became private assistant to Dr Russell at St Bartholomew's Hospital Medical School. In 1873 he returned to Burton to work as a chemist in the brewing industry for the next twenty-five years. In 1899[2] he left to become Professor of Brewing and Malting at Mason University College (which became Birmingham University in 1900).[3]
He studied the rate of fermentation of sucrose by yeast and suggested in 1892 that a substance in the yeast might be responsible for speeding up the reaction.[4] This was the first time enzymes were suggested as separate entities from organisms and talked about in chemical terms. He later studied the enzyme responsible and made the striking suggestion that the kinetics he observed were the result of an enzyme-substrate complex being formed during the reaction,[5] a concept that has formed the basis of all later work on enzyme kinetics.[6] Similar ideas had been put earlier by German chemist and Nobel laureate Hermann Emil Fischer by comparing substrate and enzyme with a key and a lock.
^"Chairs and Professors of Universities in the United Kingdom". Who's Who Year-book for 1908. 1908. p. 132.
^Knecht, E.; Thorpe, T. E.; Trigger, O.; Robertson, R. (1922). "Obituary notices: James Robert Appleyard, 1870–1921; Adrian Brown, 1852–1919; William Gowland, 1842–1922; Prof. Philippe A. Guye, 1862–1922; William Kellner, 1839–1922; George William Mac Donald; Lionel William Stansell, 1861–1922". J. Chem. Soc. Trans. 121: 2898–2916. doi:10.1039/CT9222102898.
^New Beer in an Old Bottle: Eduard Buchner and the Growth of Biochemical Knowledge 13 December 2010 at the Wayback Machine, edited by Athel Cornish-Bowden and published by Universitat de València (1997) ISBN84-370-3328-4, A history of early enzymology.
^A.J. Brown A J: Enzyme action, J. Chem. Soc. 81 (1902) 373–388
^Harden A (1 February 1920). "Obituary Notice: Adrian John Brown". Biochem. J. 14 (1): 1–3. doi:10.1042/bj0140001. PMC1258887. PMID 16742879.
Royal Society of Chemistry Biography
External linksedit
A Brief History of Enzyme Kinetics 10 February 2007 at the Wayback Machine
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adrian, john, brown, april, 1852, july, 1919, british, professor, malting, brewing, university, birmingham, pioneer, study, enzyme, kinetics, born, 1852, april, 1852burton, trent, staffordshire, englanddied2, july, 1919, 1919, aged, educationroyal, college, sc. Adrian John Brown FRS 27 April 1852 2 July 1919 1 was a British Professor of Malting and Brewing at the University of Birmingham and a pioneer in the study of enzyme kinetics Adrian John BrownBorn 1852 04 27 27 April 1852Burton on Trent Staffordshire EnglandDied2 July 1919 1919 07 02 aged 67 EducationRoyal College of Science LondonScientific careerFieldsMalting and brewing fermentation enzyme actionInstitutionsBurton on Trent St Bartholomew s Hospital London University of Birmingham Mason University College now the University of Birmingham He was born at Burton on Trent Staffordshire to Edwin Brown a bank manager in the town His elder brother was Horace Tabberer Brown He attended the local grammar school and then went up to study chemistry at the Royal College of Science in London He became private assistant to Dr Russell at St Bartholomew s Hospital Medical School In 1873 he returned to Burton to work as a chemist in the brewing industry for the next twenty five years In 1899 2 he left to become Professor of Brewing and Malting at Mason University College which became Birmingham University in 1900 3 He studied the rate of fermentation of sucrose by yeast and suggested in 1892 that a substance in the yeast might be responsible for speeding up the reaction 4 This was the first time enzymes were suggested as separate entities from organisms and talked about in chemical terms He later studied the enzyme responsible and made the striking suggestion that the kinetics he observed were the result of an enzyme substrate complex being formed during the reaction 5 a concept that has formed the basis of all later work on enzyme kinetics 6 Similar ideas had been put earlier by German chemist and Nobel laureate Hermann Emil Fischer by comparing substrate and enzyme with a key and a lock References edit See Royal Society Record here Chairs and Professors of Universities in the United Kingdom Who s Who Year book for 1908 1908 p 132 Knecht E Thorpe T E Trigger O Robertson R 1922 Obituary notices James Robert Appleyard 1870 1921 Adrian Brown 1852 1919 William Gowland 1842 1922 Prof Philippe A Guye 1862 1922 William Kellner 1839 1922 George William Mac Donald Lionel William Stansell 1861 1922 J Chem Soc Trans 121 2898 2916 doi 10 1039 CT9222102898 New Beer in an Old Bottle Eduard Buchner and the Growth of Biochemical Knowledge Archived 13 December 2010 at the Wayback Machine edited by Athel Cornish Bowden and published by Universitat de Valencia 1997 ISBN 84 370 3328 4 A history of early enzymology A J Brown A J Enzyme action J Chem Soc 81 1902 373 388 Harden A 1 February 1920 Obituary Notice Adrian John Brown Biochem J 14 1 1 3 doi 10 1042 bj0140001 PMC 1258887 PMID 16742879 Royal Society of Chemistry BiographyExternal links editA Brief History of Enzyme Kinetics Archived 10 February 2007 at the Wayback Machine nbsp This article about a British biochemist is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Adrian John Brown amp oldid 1197704797, wikipedia, wiki, book, books, library,
