Minimally differentiated acute myeloblastic leukemia is a subtype of AML. It is classified as M0 by FAB. It represents 2–3% of all cases of AML.[1] Although minimally differentiated AML was recognized earlier, criteria for FAB M0 were developed in 1987.[2] The blasts in these cases cannot be recognized as myeloid based on morphology and cytochemistry, but immunophenotyping demonstrates myeloid antigens.[3]
In acute myeloblastic leukemia (M0), the blasts are agranular and nonreactive when stained for myeloperoxidase activity, and Auer rods are not seen. The blasts react with antibodies to myeloperoxidase and antibodies to CD13, CD33, and CD34. Human leukocyte antigen (HLA)-DR is positive in most patients. Occasional cases require in situ hybridization to identify the myeloperoxidase gene315 or genomic profiling for early myeloid-associated genes.[4] Abnormal and unfavorable karyotypes (e.g., loss of the long arm of chromosome 5 (5q-) and 7q-) and higher expression of the multidrug resistance glycoprotein (p170) are frequent.[5] In general, minimally differentiated acute myeloblastic leukemia has a poor prognosis.[6]
^Testa U, Torelli GF, Riccioni R, et al. (June 2002). "Human acute stem cell leukemia with multilineage differentiation potential via cascade activation of growth factor receptors". Blood. 99 (12): 4634–7. doi:10.1182/blood.V99.12.4634. PMID 12036900.
^Lichtman M, et al. (2005). Williams Hematology (7th ed.). McGraw-Hill.
^Cuneo A, Ferrant A, Michaux JL, et al. (June 1995). "Cytogenetic profile of minimally differentiated (FAB M0) acute myeloid leukemia: correlation with clinicobiologic findings". Blood. 85 (12): 3688–94. doi:10.1182/blood.V85.12.3688.bloodjournal85123688. PMID 7780152.
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May 01, 2024
minimally, differentiated, acute, myeloblastic, leukemia, subtype, classified, represents, cases, although, minimally, differentiated, recognized, earlier, criteria, were, developed, 1987, blasts, these, cases, cannot, recognized, myeloid, based, morphology, c. Minimally differentiated acute myeloblastic leukemia is a subtype of AML It is classified as M0 by FAB It represents 2 3 of all cases of AML 1 Although minimally differentiated AML was recognized earlier criteria for FAB M0 were developed in 1987 2 The blasts in these cases cannot be recognized as myeloid based on morphology and cytochemistry but immunophenotyping demonstrates myeloid antigens 3 Minimally differentiated acute myeloblastic leukemiaThe appearance of acute myeloblastic leukemia M0 under microscope Blasts show no Auer rods SpecialtyHematology oncology Contents 1 Cytochemistry and molecular features 2 See also 3 References 4 External linksCytochemistry and molecular features editIn acute myeloblastic leukemia M0 the blasts are agranular and nonreactive when stained for myeloperoxidase activity and Auer rods are not seen The blasts react with antibodies to myeloperoxidase and antibodies to CD13 CD33 and CD34 Human leukocyte antigen HLA DR is positive in most patients Occasional cases require in situ hybridization to identify the myeloperoxidase gene315 or genomic profiling for early myeloid associated genes 4 Abnormal and unfavorable karyotypes e g loss of the long arm of chromosome 5 5q and 7q and higher expression of the multidrug resistance glycoprotein p170 are frequent 5 In general minimally differentiated acute myeloblastic leukemia has a poor prognosis 6 See also editAcute myeloid leukemia Acute myeloblastic leukemia without maturation M1 in FAB M9873 3 Acute myeloblastic leukemia with maturation M2 in FAB M9874 3References edit Kumar V Abbas AK Fausto N Mitchel RN 2007 Robbins basic Pathology 8th ed Saunders Lee EJ Pollak A Leavitt RD Testa JR Schiffer CA November 1987 Minimally differentiated acute nonlymphocytic leukemia a distinct entity Blood 70 5 1400 6 doi 10 1182 blood v70 5 1400 bloodjournal7051400 PMID 3663939 Greer JP Foerster J Lukens JN 2003 Wintrobe s Clinical Hematology 11th ed Lippincott Williams amp Wilkins Testa U Torelli GF Riccioni R et al June 2002 Human acute stem cell leukemia with multilineage differentiation potential via cascade activation of growth factor receptors Blood 99 12 4634 7 doi 10 1182 blood V99 12 4634 PMID 12036900 Lichtman M et al 2005 Williams Hematology 7th ed McGraw Hill Cuneo A Ferrant A Michaux JL et al June 1995 Cytogenetic profile of minimally differentiated FAB M0 acute myeloid leukemia correlation with clinicobiologic findings Blood 85 12 3688 94 doi 10 1182 blood V85 12 3688 bloodjournal85123688 PMID 7780152 External links edit Retrieved from https en wikipedia org w index php title Minimally differentiated acute myeloblastic leukemia amp oldid 1123588518, wikipedia, wiki, book, books, library,
