An active chromatin sequence (ACS) is a region of DNA in a eukaryoticchromosome in which histone modifications such as acetylation lead to exposure of the DNA sequence thus allowing binding of transcription factors and transcription to take place. Active chromatin may also be called euchromatin. ACSs may occur in non-expressed gene regions which are assumed to be "poised" for transcription. The sequence once exposed often contains a promoter to begin transcription. At this site acetylation or methylation can take place causing a conformational change to the chromatin. At the active chromatin sequence site deacetylation can caused the gene to be repressed if not being expressed.
active, chromatin, sequence, active, chromatin, sequence, region, eukaryotic, chromosome, which, histone, modifications, such, acetylation, lead, exposure, sequence, thus, allowing, binding, transcription, factors, transcription, take, place, active, chromatin. An active chromatin sequence ACS is a region of DNA in a eukaryotic chromosome in which histone modifications such as acetylation lead to exposure of the DNA sequence thus allowing binding of transcription factors and transcription to take place Active chromatin may also be called euchromatin ACSs may occur in non expressed gene regions which are assumed to be poised for transcription The sequence once exposed often contains a promoter to begin transcription At this site acetylation or methylation can take place causing a conformational change to the chromatin At the active chromatin sequence site deacetylation can caused the gene to be repressed if not being expressed Heterochromatin vs euchromatinSee also EditChromatinReferences EditSabo PJ Humbert R Hawrylycz M et al March 2004 Genome wide identification of DNaseI hypersensitive sites using active chromatin sequence libraries Proc Natl Acad Sci U S A 101 13 4537 42 Bibcode 2004PNAS 101 4537S doi 10 1073 pnas 0400678101 PMC 384782 PMID 15070753 Roh TY Cuddapah S Zhao K 2005 Active chromatin domains are defined by acetylation islands revealed by genome wide mapping Genes Dev 19 5 542 52 doi 10 1101 gad 1272505 PMC 551575 PMID 15706033 nbsp This genetics article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Active chromatin sequence amp oldid 1116599886, wikipedia, wiki, book, books, library,
