Actinic elastosis, also known as solar elastosis, is an accumulation of abnormal elastin (elastic tissue) in the dermis of the skin,[2] or in the conjunctiva of the eye,[3] which occurs as a result of the cumulative effects of prolonged and excessive sun exposure, a process known as photoaging.
Actinic elastosis
Other names
Solar elastosis
Micrograph showing solar elastosis - grey, jumbled spaghetti-like material on bottom of image. H&E stain.
Actinic elastosis usually appears as thickened, dry, wrinkled skin. Several clinical variants have been recorded. One of the most readily identifiable is the thickened, deeply fissured skin seen on the back of the chronically sun-exposed neck, known as cutis rhomboidalis nuchae.[2] These features are a part of the constellation of changes that are seen in photoaged skin.[2]
Causesedit
The origin of the elastotic material in the dermis remains a subject of debate. Theories on the formation of the elastotic material include actinic stimulation of fibroblasts, promoting synthesis of this material, or that the material is a degradation product of collagen, elastin, or both.[2]
Diagnosisedit
In the earlier stages of actinic elastosis, elastic fiber proliferation can be seen in the dermis. As the condition becomes more established, the collagen fibers of the papillary dermis and reticular dermis become increasingly replaced by thickened and curled fibers that form tangled masses and appear basophilic under routine haematoxylin and eosin staining. These fibers stain black with the Verhoeff stain.[2]
The most effective prevention strategy for photoaging remains minimization of sun exposure, through use of sunscreen and other sun exposure avoidance measures.[2]
Referencesedit
^Kim, Miri; Park, Hyun Jeong (2016). "Molecular Mechanisms of Skin Aging and Rejuvenation". Molecular Mechanisms of the Aging Process and Rejuvenation. InTech Open. doi:10.5772/62983. ISBN978-953-51-2568-6.
^Klintworth, G; Cummings, T (2009-08-26). "24; The eye and ocular adnexa". In Stacey, Mills (ed.). Sternberg's Diagnostic Surgical Pathology (5 ed.). ISBN978-0-7817-7942-5.
External linksedit
at DermIS.net
April 10, 2024
actinic, elastosis, also, known, solar, elastosis, accumulation, abnormal, elastin, elastic, tissue, dermis, skin, conjunctiva, which, occurs, result, cumulative, effects, prolonged, excessive, exposure, process, known, photoaging, other, namessolar, elastosis. Actinic elastosis also known as solar elastosis is an accumulation of abnormal elastin elastic tissue in the dermis of the skin 2 or in the conjunctiva of the eye 3 which occurs as a result of the cumulative effects of prolonged and excessive sun exposure a process known as photoaging Actinic elastosisOther namesSolar elastosisMicrograph showing solar elastosis grey jumbled spaghetti like material on bottom of image H amp E stain SpecialtyDermatologySolar elastosis separates from the epidermis by a narrow band of normal appearing collagen grenz zone with collagen fibers arranged horizontally 1 Contents 1 Signs and symptoms 2 Causes 3 Diagnosis 4 Treatment 5 References 6 External linksSigns and symptoms editActinic elastosis usually appears as thickened dry wrinkled skin Several clinical variants have been recorded One of the most readily identifiable is the thickened deeply fissured skin seen on the back of the chronically sun exposed neck known as cutis rhomboidalis nuchae 2 These features are a part of the constellation of changes that are seen in photoaged skin 2 Causes editThe origin of the elastotic material in the dermis remains a subject of debate Theories on the formation of the elastotic material include actinic stimulation of fibroblasts promoting synthesis of this material or that the material is a degradation product of collagen elastin or both 2 Diagnosis editIn the earlier stages of actinic elastosis elastic fiber proliferation can be seen in the dermis As the condition becomes more established the collagen fibers of the papillary dermis and reticular dermis become increasingly replaced by thickened and curled fibers that form tangled masses and appear basophilic under routine haematoxylin and eosin staining These fibers stain black with the Verhoeff stain 2 Treatment editNumerous treatment options are available for photoaged skin including dermabrasion topical application of retinoic acid carbon dioxide laser resurfacing hyaluronic acid injection into the dermis imiquimod tacrolimus ointment and topical oestrogen therapy These treatments have variable efficacy 2 The most effective prevention strategy for photoaging remains minimization of sun exposure through use of sunscreen and other sun exposure avoidance measures 2 References edit Kim Miri Park Hyun Jeong 2016 Molecular Mechanisms of Skin Aging and Rejuvenation Molecular Mechanisms of the Aging Process and Rejuvenation InTech Open doi 10 5772 62983 ISBN 978 953 51 2568 6 a b c d e f g Weedon David 2010 Weedon s Skin Pathology 3rd Edition Elsevier ISBN 978 0 7020 3485 5 Klintworth G Cummings T 2009 08 26 24 The eye and ocular adnexa In Stacey Mills ed Sternberg s Diagnostic Surgical Pathology 5 ed ISBN 978 0 7817 7942 5 External links editPicture of solar elastosis at DermIS net Retrieved from https en wikipedia org w index php title Actinic elastosis amp oldid 1172387056, wikipedia, wiki, book, books, library,
