3 malonyl-CoA + N-methylanthraniloyl-CoA 4 CoA + 1,3-dihydroxy-N-methylacridone + 3 CO2
Thus, the two substrates of this enzyme are malonyl-CoA and N-methylanthraniloyl-CoA, whereas its 3 products are CoA, 1,3-dihydroxy-N-methylacridone, and CO2.
This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is malonyl-CoA:N-methylanthraniloyl-CoA malonyltransferase (cyclizing). This enzyme participates in acridone alkaloid biosynthesis.
Referencesedit
Baumert A, Maier W, Gröger D, Deutzmann R (1994). "Purification and properties of acridone synthase from cell suspension cultures of Ruta graveolens L". Z. Naturforsch. C. 49 (1–2): 26–32. PMID 8148006.
Maier W, Baumert A, Schumann B, Furukawa H, Gröger D (1993). "Synthesis of 1,3-dihydroxy-N-methylacridone and its conversion to rutacridone by cell-free extracts of Ruta-graveolens cell cultures". Phytochemistry. 32 (3): 691–698. doi:10.1016/S0031-9422(00)95155-0.
Matern U; Springob, K; Urbanke, C; Ernwein, C; Schröder, G; Schröder, J; Matern, U (1999). "Native acridone synthases I and II from Ruta graveolens L. form homodimers". FEBS Lett. 448 (1): 135–40. doi:10.1016/S0014-5793(99)00355-5. PMID 10217426.
Junghanns KT, Kneusel RE, Gröger D, Matern U (1998). "Differential regulation and distribution of acridone synthase in Ruta graveolens". Phytochemistry. 49 (2): 403–11. doi:10.1016/S0031-9422(98)00104-6. PMID 9747538.
acridone, synthase, enzymology, acridone, synthase, enzyme, that, catalyzes, chemical, reactionacridone, synthaseidentifiersec, 159cas, 99085, 7databasesintenzintenz, viewbrendabrenda, entryexpasynicezyme, viewkeggkegg, entrymetacycmetabolic, pathwaypriamprofi. In enzymology an acridone synthase EC 2 3 1 159 is an enzyme that catalyzes the chemical reactionacridone synthaseIdentifiersEC no 2 3 1 159CAS no 99085 53 7DatabasesIntEnzIntEnz viewBRENDABRENDA entryExPASyNiceZyme viewKEGGKEGG entryMetaCycmetabolic pathwayPRIAMprofilePDB structuresRCSB PDB PDBe PDBsumGene OntologyAmiGO QuickGOSearchPMCarticlesPubMedarticlesNCBIproteins 3 malonyl CoA N methylanthraniloyl CoA displaystyle rightleftharpoons 4 CoA 1 3 dihydroxy N methylacridone 3 CO2Thus the two substrates of this enzyme are malonyl CoA and N methylanthraniloyl CoA whereas its 3 products are CoA 1 3 dihydroxy N methylacridone and CO2 This enzyme belongs to the family of transferases specifically those acyltransferases transferring groups other than aminoacyl groups The systematic name of this enzyme class is malonyl CoA N methylanthraniloyl CoA malonyltransferase cyclizing This enzyme participates in acridone alkaloid biosynthesis References editBaumert A Maier W Groger D Deutzmann R 1994 Purification and properties of acridone synthase from cell suspension cultures of Ruta graveolens L Z Naturforsch C 49 1 2 26 32 PMID 8148006 Maier W Baumert A Schumann B Furukawa H Groger D 1993 Synthesis of 1 3 dihydroxy N methylacridone and its conversion to rutacridone by cell free extracts of Ruta graveolens cell cultures Phytochemistry 32 3 691 698 doi 10 1016 S0031 9422 00 95155 0 Matern U Springob K Urbanke C Ernwein C Schroder G Schroder J Matern U 1999 Native acridone synthases I and II from Ruta graveolens L form homodimers FEBS Lett 448 1 135 40 doi 10 1016 S0014 5793 99 00355 5 PMID 10217426 Junghanns KT Kneusel RE Groger D Matern U 1998 Differential regulation and distribution of acridone synthase in Ruta graveolens Phytochemistry 49 2 403 11 doi 10 1016 S0031 9422 98 00104 6 PMID 9747538 Portal nbsp Biology This EC 2 3 enzyme related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Acridone synthase amp oldid 1172338288, wikipedia, wiki, book, books, library,
