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ADAMTS-4 endopeptidase

April 13, 2024

ADAMTS-4 endopeptidase (EC 3.4.24.82, aggrecanase-1) is an enzyme.[1] This enzyme catalyses the following chemical reaction

ADAMTS-4 endopeptidase
Identifiers
EC no.3.4.24.82
CAS no.147172-61-0
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins
Glutamyl endopeptidase; bonds cleaved include -Thr-Glu-Gly-Glu373-Ala-Arg-Gly-Ser- in the interglobular domain of mammalian aggrecan

This enzyme belongs to the peptidase family M12.

References edit

  1. ^ Westling J, Fosang AJ, Last K, Thompson VP, Tomkinson KN, Hebert T, McDonagh T, Collins-Racie LA, LaVallie ER, Morris EA, Sandy JD (May 2002). "ADAMTS4 cleaves at the aggrecanase site (Glu373-Ala374) and secondarily at the matrix metalloproteinase site (Asn341-Phe342) in the aggrecan interglobular domain". The Journal of Biological Chemistry. 277 (18): 16059–66. doi:10.1074/jbc.M108607200. PMID 11854269.

External links edit

April 13, 2024
adamts, endopeptidase, aggrecanase, enzyme, this, enzyme, catalyses, following, chemical, reactionidentifiersec, 82cas, 147172, 0databasesintenzintenz, viewbrendabrenda, entryexpasynicezyme, viewkeggkegg, entrymetacycmetabolic, pathwaypriamprofilepdb, structur. ADAMTS 4 endopeptidase EC 3 4 24 82 aggrecanase 1 is an enzyme 1 This enzyme catalyses the following chemical reactionADAMTS 4 endopeptidaseIdentifiersEC no 3 4 24 82CAS no 147172 61 0DatabasesIntEnzIntEnz viewBRENDABRENDA entryExPASyNiceZyme viewKEGGKEGG entryMetaCycmetabolic pathwayPRIAMprofilePDB structuresRCSB PDB PDBe PDBsumSearchPMCarticlesPubMedarticlesNCBIproteins Glutamyl endopeptidase bonds cleaved include Thr Glu Gly Glu373 Ala Arg Gly Ser in the interglobular domain of mammalian aggrecanThis enzyme belongs to the peptidase family M12 References edit Westling J Fosang AJ Last K Thompson VP Tomkinson KN Hebert T McDonagh T Collins Racie LA LaVallie ER Morris EA Sandy JD May 2002 ADAMTS4 cleaves at the aggrecanase site Glu373 Ala374 and secondarily at the matrix metalloproteinase site Asn341 Phe342 in the aggrecan interglobular domain The Journal of Biological Chemistry 277 18 16059 66 doi 10 1074 jbc M108607200 PMID 11854269 External links editADAMTS 4 endopeptidase at the U S National Library of Medicine Medical Subject Headings MeSH Portal nbsp Biology Retrieved from https en wikipedia org w index php title ADAMTS 4 endopeptidase amp oldid 1172338483, wikipedia, wiki, book, books, library,

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