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Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase

In enzymology, an alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase (EC 2.4.99.3) is an enzyme that catalyzes the chemical reaction

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase
Identifiers
EC no.2.4.99.3
CAS no.71124-50-0
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins
CMP-N-acetylneuraminate + glycano-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein CMP + glycano-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)- glycoprotein

Thus, the two substrates of this enzyme are CMP-N-acetylneuraminate and glycano-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein, whereas its 3 products are CMP, glycano-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-, and glycoprotein.

This enzyme belongs to the family of transferases, specifically those glycosyltransferases that do not transfer hexosyl or pentosyl groups. The systematic name of this enzyme class is CMP-N-acetylneuraminate:glycano-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein alpha-2,6-N-acetylneuraminyltransferase. This enzyme participates in o-glycan biosynthesis and glycan structures - biosynthesis 1.

References edit

  • Sadler JE, Rearick JI, Hill RL (1979). "Purification to homogeneity and enzymatic characterization of an alpha-N-acetylgalactosaminide alpha 2 leads to 6 sialyltransferase from porcine submaxillary glands". J. Biol. Chem. 254 (13): 5934–41. PMID 447688.


alpha, acetylgalactosaminide, alpha, sialyltransferase, enzymology, alpha, acetylgalactosaminide, alpha, sialyltransferase, enzyme, that, catalyzes, chemical, reactionalpha, acetylgalactosaminide, alpha, sialyltransferaseidentifiersec, 3cas, 71124, 0databasesi. In enzymology an alpha N acetylgalactosaminide alpha 2 6 sialyltransferase EC 2 4 99 3 is an enzyme that catalyzes the chemical reactionalpha N acetylgalactosaminide alpha 2 6 sialyltransferaseIdentifiersEC no 2 4 99 3CAS no 71124 50 0DatabasesIntEnzIntEnz viewBRENDABRENDA entryExPASyNiceZyme viewKEGGKEGG entryMetaCycmetabolic pathwayPRIAMprofilePDB structuresRCSB PDB PDBe PDBsumGene OntologyAmiGO QuickGOSearchPMCarticlesPubMedarticlesNCBIproteins CMP N acetylneuraminate glycano 1 3 N acetyl alpha D galactosaminyl glycoprotein displaystyle rightleftharpoons CMP glycano 2 6 alpha N acetylneuraminyl N acetyl D galactosaminyl glycoproteinThus the two substrates of this enzyme are CMP N acetylneuraminate and glycano 1 3 N acetyl alpha D galactosaminyl glycoprotein whereas its 3 products are CMP glycano 2 6 alpha N acetylneuraminyl N acetyl D galactosaminyl and glycoprotein This enzyme belongs to the family of transferases specifically those glycosyltransferases that do not transfer hexosyl or pentosyl groups The systematic name of this enzyme class is CMP N acetylneuraminate glycano 1 3 N acetyl alpha D galactosaminyl glycoprotein alpha 2 6 N acetylneuraminyltransferase This enzyme participates in o glycan biosynthesis and glycan structures biosynthesis 1 References editSadler JE Rearick JI Hill RL 1979 Purification to homogeneity and enzymatic characterization of an alpha N acetylgalactosaminide alpha 2 leads to 6 sialyltransferase from porcine submaxillary glands J Biol Chem 254 13 5934 41 PMID 447688 Portal nbsp Biology This EC 2 4 enzyme related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Alpha N acetylgalactosaminide alpha 2 6 sialyltransferase amp oldid 1198277892, wikipedia, wiki, book, books, library,

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