Cytoplasmicribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein, which shares sequence similarity with yeast ribosomal protein L44, belongs to the L44E (L36AE) family of ribosomal proteins. Although this gene has been referred to as ribosomal protein L44 (RPL44), its official name is ribosomal protein L36a (RPL36A). This gene and the human gene officially named ribosomal protein L36a-like (RPL36AL) encode nearly identical proteins; however, they are distinct genes. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[4]
Referencesedit
^ abcGRCh38: Ensembl release 89: ENSG00000241343 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Dixit VM, Hennessy SW, Grant GA, Rotwein P, Frazier WA (Sep 1986). "Characterization of a cDNA encoding the heparin and collagen binding domains of human thrombospondin". Proc Natl Acad Sci U S A. 83 (15): 5449–53. Bibcode:1986PNAS...83.5449D. doi:10.1073/pnas.83.15.5449. PMC386304. PMID 3461443.
Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–47. doi:10.1139/o95-101. PMID 8722009.
Davies MS, Henney A, Ward WH, Craig RK (1987). "Characterisation of an mRNA encoding a human ribosomal protein homologous to the yeast L44 ribosomal protein". Gene. 45 (2): 183–91. doi:10.1016/0378-1119(86)90253-2. PMID 3542712.
Oeltjen JC, Liu X, Lu J, et al. (1995). "Sixty-nine kilobases of contiguous human genomic sequence containing the alpha-galactosidase A and Bruton's tyrosine kinase loci". Mamm. Genome. 6 (5): 334–8. doi:10.1007/BF00364796. PMID 7626884. S2CID 22686077.
Kato S, Sekine S, Oh SW, et al. (1995). "Construction of a human full-length cDNA bank". Gene. 150 (2): 243–50. doi:10.1016/0378-1119(94)90433-2. PMID 7821789.
Vorechovský I, Vetrie D, Holland J, et al. (1994). "Isolation of cosmid and cDNA clones in the region surrounding the BTK gene at Xq21.3-q22". Genomics. 21 (3): 517–24. doi:10.1006/geno.1994.1310. PMID 7959728.
Cross SH, Charlton JA, Nan X, Bird AP (1994). "Purification of CpG islands using a methylated DNA binding column". Nat. Genet. 6 (3): 236–44. doi:10.1038/ng0394-236. PMID 8012384. S2CID 12847618.
Oeltjen JC, Malley TM, Muzny DM, et al. (1997). "Large-scale comparative sequence analysis of the human and murine Bruton's tyrosine kinase loci reveals conserved regulatory domains". Genome Res. 7 (4): 315–29. doi:10.1101/gr.7.4.315. PMID 9110171.
Gubin AN, Njoroge JM, Bouffard GG, Miller JL (1999). "Gene expression in proliferating human erythroid cells". Genomics. 59 (2): 168–77. doi:10.1006/geno.1999.5855. PMID 10409428.
Uechi T, Tanaka T, Kenmochi N (2001). "A complete map of the human ribosomal protein genes: assignment of 80 genes to the cytogenetic map and implications for human disorders". Genomics. 72 (3): 223–30. doi:10.1006/geno.2000.6470. PMID 11401437.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Kim JH, You KR, Kim IH, et al. (2004). "Over-expression of the ribosomal protein L36a gene is associated with cellular proliferation in hepatocellular carcinoma". Hepatology. 39 (1): 129–38. doi:10.1002/hep.20017. PMID 14752831. S2CID 36029858.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC528928. PMID 15489334.
Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. Bibcode:2005Natur.434..325R. doi:10.1038/nature03440. PMC2665286. PMID 15772651.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC1847948. PMID 17353931.
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ribosomal, protein, l36a, protein, that, humans, encoded, rpl36a, gene, rpl36aavailable, structurespdbhuman, uniprot, search, pdbe, rcsblist, codes4ug0, 4v6x, 5aj0, 3j7r, 4v5z, 4ujd, 3j7p, 4d67, 3j92, 4d5y, 3j7q, 4uje, 3j7o, 4ujcidentifiersaliasesrpl36a, l36a,. 60S ribosomal protein L36a is a protein that in humans is encoded by the RPL36A gene 3 4 RPL36AAvailable structuresPDBHuman UniProt search PDBe RCSBList of PDB id codes4UG0 4V6X 5AJ0 3J7R 4V5Z 4UJD 3J7P 4D67 3J92 4D5Y 3J7Q 4UJE 3J7O 4UJCIdentifiersAliasesRPL36A L36A L44L MIG6 RPL44 ribosomal protein L36aExternal IDsOMIM 300902 HomoloGene 776 GeneCards RPL36AGene location Human Chr X chromosome human 1 BandXq22 1Start101 390 824 bp 1 End101 396 155 bp 1 RNA expression patternBgeeHumanMouse ortholog Top expressed inganglionic eminenceright uterine tubeskin of abdomencervixrenal cortexcanal of the cervixbody of pancreaslymph nodebone marrow cellsthymusn aMore reference expression dataBioGPSn aGene ontologyMolecular functionstructural constituent of ribosome protein binding RNA bindingCellular componentcytoplasm ribosome intracellular anatomical structure cytosolic large ribosomal subunit cytosol plasma membrane endoplasmic reticulum polysomal ribosomeBiological processcytoplasmic translation viral transcription SRP dependent cotranslational protein targeting to membrane translational initiation nuclear transcribed mRNA catabolic process nonsense mediated decay protein biosynthesis rRNA processingSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez6173n aEnsemblENSG00000241343n aUniProtP83881n aRefSeq mRNA NM 021029NM 001199972n aRefSeq protein NP 066357n aLocation UCSC Chr X 101 39 101 4 Mbn aPubMed search 2 n aWikidataView Edit Human Cytoplasmic ribosomes organelles that catalyze protein synthesis consist of a small 40S subunit and a large 60S subunit Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins This gene encodes a ribosomal protein that is a component of the 60S subunit The protein which shares sequence similarity with yeast ribosomal protein L44 belongs to the L44E L36AE family of ribosomal proteins Although this gene has been referred to as ribosomal protein L44 RPL44 its official name is ribosomal protein L36a RPL36A This gene and the human gene officially named ribosomal protein L36a like RPL36AL encode nearly identical proteins however they are distinct genes As is typical for genes encoding ribosomal proteins there are multiple processed pseudogenes of this gene dispersed through the genome 4 References edit a b c GRCh38 Ensembl release 89 ENSG00000241343 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Dixit VM Hennessy SW Grant GA Rotwein P Frazier WA Sep 1986 Characterization of a cDNA encoding the heparin and collagen binding domains of human thrombospondin Proc Natl Acad Sci U S A 83 15 5449 53 Bibcode 1986PNAS 83 5449D doi 10 1073 pnas 83 15 5449 PMC 386304 PMID 3461443 a b Entrez Gene RPL36A ribosomal protein L36a Further reading editWool IG Chan YL Gluck A 1996 Structure and evolution of mammalian ribosomal proteins Biochem Cell Biol 73 11 12 933 47 doi 10 1139 o95 101 PMID 8722009 Davies MS Henney A Ward WH Craig RK 1987 Characterisation of an mRNA encoding a human ribosomal protein homologous to the yeast L44 ribosomal protein Gene 45 2 183 91 doi 10 1016 0378 1119 86 90253 2 PMID 3542712 Oeltjen JC Liu X Lu J et al 1995 Sixty nine kilobases of contiguous human genomic sequence containing the alpha galactosidase A and Bruton s tyrosine kinase loci Mamm Genome 6 5 334 8 doi 10 1007 BF00364796 PMID 7626884 S2CID 22686077 Kato S Sekine S Oh SW et al 1995 Construction of a human full length cDNA bank Gene 150 2 243 50 doi 10 1016 0378 1119 94 90433 2 PMID 7821789 Vorechovsky I Vetrie D Holland J et al 1994 Isolation of cosmid and cDNA clones in the region surrounding the BTK gene at Xq21 3 q22 Genomics 21 3 517 24 doi 10 1006 geno 1994 1310 PMID 7959728 Cross SH Charlton JA Nan X Bird AP 1994 Purification of CpG islands using a methylated DNA binding column Nat Genet 6 3 236 44 doi 10 1038 ng0394 236 PMID 8012384 S2CID 12847618 Oeltjen JC Malley TM Muzny DM et al 1997 Large scale comparative sequence analysis of the human and murine Bruton s tyrosine kinase loci reveals conserved regulatory domains Genome Res 7 4 315 29 doi 10 1101 gr 7 4 315 PMID 9110171 Gubin AN Njoroge JM Bouffard GG Miller JL 1999 Gene expression in proliferating human erythroid cells Genomics 59 2 168 77 doi 10 1006 geno 1999 5855 PMID 10409428 Uechi T Tanaka T Kenmochi N 2001 A complete map of the human ribosomal protein genes assignment of 80 genes to the cytogenetic map and implications for human disorders Genomics 72 3 223 30 doi 10 1006 geno 2000 6470 PMID 11401437 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Ota T Suzuki Y Nishikawa T et al 2004 Complete sequencing and characterization of 21 243 full length human cDNAs Nat Genet 36 1 40 5 doi 10 1038 ng1285 PMID 14702039 Kim JH You KR Kim IH et al 2004 Over expression of the ribosomal protein L36a gene is associated with cellular proliferation in hepatocellular carcinoma Hepatology 39 1 129 38 doi 10 1002 hep 20017 PMID 14752831 S2CID 36029858 Gerhard DS Wagner L Feingold EA et al 2004 The Status Quality and Expansion of the NIH Full Length cDNA Project The Mammalian Gene Collection MGC Genome Res 14 10B 2121 7 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 Ross MT Grafham DV Coffey AJ et al 2005 The DNA sequence of the human X chromosome Nature 434 7031 325 37 Bibcode 2005Natur 434 325R doi 10 1038 nature03440 PMC 2665286 PMID 15772651 Ewing RM Chu P Elisma F et al 2007 Large scale mapping of human protein protein interactions by mass spectrometry Mol Syst Biol 3 1 89 doi 10 1038 msb4100134 PMC 1847948 PMID 17353931 nbsp This protein related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title 60S ribosomal protein L36a amp oldid 1183926434, wikipedia, wiki, book, books, library,
