Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L23P family of ribosomal proteins. It is located in the cytoplasm. The protein may be one of the target molecules involved in mediating growth inhibition by interferon. In yeast, the corresponding protein binds to a specific site on the 26S rRNA. This gene is co-transcribed with the U42A, U42B, U101A, and U101B small nucleolar RNA genes, which are located in its third, first, second, and fourth introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[4]
Clinical significanceedit
L23a has been identified as an autoimmune target that causes a form of rheumatoid arthritis in mice and which also causes a reaction from T cells and autoantibodies from human rheumatoid arthritis patients.[5]
Referencesedit
^ abcGRCh38: Ensembl release 89: ENSG00000198242 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Fan W, Christensen M, Eichler E, Zhang X, Lennon G (Feb 1998). "Cloning, sequencing, gene organization, and localization of the human ribosomal protein RPL23A gene". Genomics. 46 (2): 234–9. doi:10.1006/geno.1997.5038. PMID 9417910.
^Ito Y, Hashimoto M, Hirota K, Ohkura N, Morikawa H, Nishikawa H, Tanaka A, Furu M, Ito H, Fujii T, Nomura T, Yamazaki S, Morita A, Vignali DA, Kappler JW, Matsuda S, Mimori T, Sakaguchi N, Sakaguchi S (2014). "Detection of T cell responses to a ubiquitous cellular protein in autoimmune disease". Science. 346 (6207): 363–8. Bibcode:2014Sci...346..363I. doi:10.1126/science.1259077. PMC5554397. PMID 25324392.
Further readingedit
Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–47. doi:10.1139/o95-101. PMID 8722009.
Fan W, Cai W, Parimoo S, Schwarz DC, Lennon GG, Weissman SM (1996). "Identification of seven new human MHC class I region genes around the HLA-F locus". Immunogenetics. 44 (2): 97–103. doi:10.1007/BF02660056. PMID 8662070. S2CID 21628804.
Jiang H, Lin JJ, Tao J, Fisher PB (1997). "Suppression of human ribosomal protein L23A expression during cell growth inhibition by interferon-beta". Oncogene. 14 (4): 473–80. doi:10.1038/sj.onc.1200858. PMID 9053844.
Jäkel S, Görlich D (1998). "Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells". EMBO J. 17 (15): 4491–502. doi:10.1093/emboj/17.15.4491. PMC1170780. PMID 9687515.
Rogan S, Heaphy S (2001). "The vaccinia virus E3L protein interacts with SUMO-1 and ribosomal protein L23a in a yeast two hybrid assay". Virus Genes. 21 (3): 193–5. doi:10.1023/A:1008139514123. PMID 11129635. S2CID 8941317.
Uechi T, Tanaka T, Kenmochi N (2001). "A complete map of the human ribosomal protein genes: assignment of 80 genes to the cytogenetic map and implications for human disorders". Genomics. 72 (3): 223–30. doi:10.1006/geno.2000.6470. PMID 11401437.
Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC515316. PMID 15342556.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC1847948. PMID 17353931.
External linksedit
PDBe-KB provides an overview of all the structure information available in the PDB for Human 60S ribosomal protein L23a
This protein-related article is a stub. You can help Wikipedia by expanding it.
ribosomal, protein, l23a, protein, that, humans, encoded, rpl23a, gene, rpl23aavailable, structurespdbhuman, uniprot, search, pdbe, rcsblist, codes4ug0, 4v6x, 5aj0, 3j7r, 4v5z, 4ujd, 3j7p, 4d67, 3j92, 4d5y, 3j7q, 4uje, 3j7o, 4ujcidentifiersaliasesrpl23a, l23a,. 60S ribosomal protein L23a is a protein that in humans is encoded by the RPL23A gene 3 4 RPL23AAvailable structuresPDBHuman UniProt search PDBe RCSBList of PDB id codes4UG0 4V6X 5AJ0 3J7R 4V5Z 4UJD 3J7P 4D67 3J92 4D5Y 3J7Q 4UJE 3J7O 4UJCIdentifiersAliasesRPL23A L23A MDA20 ribosomal protein L23aExternal IDsOMIM 602326 HomoloGene 133569 GeneCards RPL23AGene location Human Chr Chromosome 17 human 1 Band17q11 2Start28 719 985 bp 1 End28 724 359 bp 1 RNA expression patternBgeeHumanMouse ortholog Top expressed inAchilles tendoncanal of the cervixright uterine tubepituitary glandskin of abdomenanterior pituitaryleft uterine tubeganglionic eminencethymusprostaten aMore reference expression dataBioGPSn aGene ontologyMolecular functionrRNA binding structural constituent of ribosome protein binding cadherin binding RNA binding TORC2 complex binding large ribosomal subunit rRNA bindingCellular componentcytoplasm cytosol ribosome intracellular anatomical structure nucleolus cytosolic large ribosomal subunit extracellular exosome nucleus TORC2 complexBiological processviral transcription SRP dependent cotranslational protein targeting to membrane ribosomal large subunit assembly translational initiation nuclear transcribed mRNA catabolic process nonsense mediated decay cell population proliferation protein biosynthesis rRNA processingSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez6147n aEnsemblENSG00000198242n aUniProtP62750n aRefSeq mRNA NM 000984n aRefSeq protein NP 000975n aLocation UCSC Chr 17 28 72 28 72 Mbn aPubMed search 2 n aWikidataView Edit Human Contents 1 Function 2 Clinical significance 3 References 4 Further reading 5 External linksFunction editRibosomes the organelles that catalyze protein synthesis consist of a small 40S subunit and a large 60S subunit Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins This gene encodes a ribosomal protein that is a component of the 60S subunit The protein belongs to the L23P family of ribosomal proteins It is located in the cytoplasm The protein may be one of the target molecules involved in mediating growth inhibition by interferon In yeast the corresponding protein binds to a specific site on the 26S rRNA This gene is co transcribed with the U42A U42B U101A and U101B small nucleolar RNA genes which are located in its third first second and fourth introns respectively As is typical for genes encoding ribosomal proteins there are multiple processed pseudogenes of this gene dispersed through the genome 4 Clinical significance editL23a has been identified as an autoimmune target that causes a form of rheumatoid arthritis in mice and which also causes a reaction from T cells and autoantibodies from human rheumatoid arthritis patients 5 References edit a b c GRCh38 Ensembl release 89 ENSG00000198242 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Fan W Christensen M Eichler E Zhang X Lennon G Feb 1998 Cloning sequencing gene organization and localization of the human ribosomal protein RPL23A gene Genomics 46 2 234 9 doi 10 1006 geno 1997 5038 PMID 9417910 a b Entrez Gene RPL23A ribosomal protein L23a Ito Y Hashimoto M Hirota K Ohkura N Morikawa H Nishikawa H Tanaka A Furu M Ito H Fujii T Nomura T Yamazaki S Morita A Vignali DA Kappler JW Matsuda S Mimori T Sakaguchi N Sakaguchi S 2014 Detection of T cell responses to a ubiquitous cellular protein in autoimmune disease Science 346 6207 363 8 Bibcode 2014Sci 346 363I doi 10 1126 science 1259077 PMC 5554397 PMID 25324392 Further reading editWool IG Chan YL Gluck A 1996 Structure and evolution of mammalian ribosomal proteins Biochem Cell Biol 73 11 12 933 47 doi 10 1139 o95 101 PMID 8722009 Fan W Cai W Parimoo S Schwarz DC Lennon GG Weissman SM 1996 Identification of seven new human MHC class I region genes around the HLA F locus Immunogenetics 44 2 97 103 doi 10 1007 BF02660056 PMID 8662070 S2CID 21628804 Jiang H Lin JJ Tao J Fisher PB 1997 Suppression of human ribosomal protein L23A expression during cell growth inhibition by interferon beta Oncogene 14 4 473 80 doi 10 1038 sj onc 1200858 PMID 9053844 Jakel S Gorlich D 1998 Importin beta transportin RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells EMBO J 17 15 4491 502 doi 10 1093 emboj 17 15 4491 PMC 1170780 PMID 9687515 Rogan S Heaphy S 2001 The vaccinia virus E3L protein interacts with SUMO 1 and ribosomal protein L23a in a yeast two hybrid assay Virus Genes 21 3 193 5 doi 10 1023 A 1008139514123 PMID 11129635 S2CID 8941317 Uechi T Tanaka T Kenmochi N 2001 A complete map of the human ribosomal protein genes assignment of 80 genes to the cytogenetic map and implications for human disorders Genomics 72 3 223 30 doi 10 1006 geno 2000 6470 PMID 11401437 Andersen JS Lyon CE Fox AH Leung AK Lam YW Steen H Mann M Lamond AI 2002 Directed proteomic analysis of the human nucleolus Curr Biol 12 1 1 11 Bibcode 2002CBio 12 1A doi 10 1016 S0960 9822 01 00650 9 PMID 11790298 S2CID 14132033 Suzuki Y Yamashita R Shirota M Sakakibara Y Chiba J Mizushima Sugano J Nakai K Sugano S 2004 Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions Genome Res 14 9 1711 8 doi 10 1101 gr 2435604 PMC 515316 PMID 15342556 Olsen JV Blagoev B Gnad F Macek B Kumar C Mortensen P Mann M 2006 Global in vivo and site specific phosphorylation dynamics in signaling networks Cell 127 3 635 48 doi 10 1016 j cell 2006 09 026 PMID 17081983 S2CID 7827573 Ewing RM Chu P Elisma F Li H Taylor P Climie S McBroom Cerajewski L Robinson MD O Connor L Li M Taylor R Dharsee M Ho Y Heilbut A Moore L Zhang S Ornatsky O Bukhman YV Ethier M Sheng Y Vasilescu J Abu Farha M Lambert JP Duewel HS Stewart II Kuehl B Hogue K Colwill K Gladwish K Muskat B Kinach R Adams SL Moran MF Morin GB Topaloglou T Figeys D 2007 Large scale mapping of human protein protein interactions by mass spectrometry Mol Syst Biol 3 1 89 doi 10 1038 msb4100134 PMC 1847948 PMID 17353931 External links editPDBe KB provides an overview of all the structure information available in the PDB for Human 60S ribosomal protein L23a nbsp This protein related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title 60S ribosomal protein L23a amp oldid 1221253313, wikipedia, wiki, book, books, library,
