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4-hydroxyphenylacetate 1-monooxygenase

In enzymology, a 4-hydroxyphenylacetate 1-monooxygenase (EC 1.14.13.18) is an enzyme that catalyzes the chemical reaction

4-hydroxyphenylacetate 1-monooxygenase
Identifiers
EC no.1.14.13.18
CAS no.55326-44-8
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins
4-hydroxyphenylacetate + NAD(P)H + H+ + O2 homogentisate + NAD(P)+ + H2O

The 5 substrates of this enzyme are 4-hydroxyphenylacetate, NADH, NADPH, H+, and O2, whereas its 4 products are homogentisate, NAD+, NADP+, and H2O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and incorporation of one atom o oxygen into the other donor. The systematic name of this enzyme class is 4-hydroxyphenylacetate,NAD(P)H:oxygen oxidoreductase (1-hydroxylating). Other names in common use include 4-hydroxyphenylacetate 1-hydroxylase, 4-hydroxyphenylacetic 1-hydroxylase, and 4-HPA 1-hydroxylase. This enzyme participates in tyrosine metabolism.. It employs one cofactor, FAD.

References edit

  • Hareland WA, Crawford RL, Chapman PJ, Dagley S (1975). "Metabolic function and properties of 4-hydroxyphenylacetic acid 1-hydroxylase from Pseudomonas acidovorans". J. Bacteriol. 121 (1): 272–85. PMC 285641. PMID 234937.


hydroxyphenylacetate, monooxygenase, enzymology, enzyme, that, catalyzes, chemical, reactionidentifiersec, 18cas, 55326, 8databasesintenzintenz, viewbrendabrenda, entryexpasynicezyme, viewkeggkegg, entrymetacycmetabolic, pathwaypriamprofilepdb, structuresrcsb,. In enzymology a 4 hydroxyphenylacetate 1 monooxygenase EC 1 14 13 18 is an enzyme that catalyzes the chemical reaction4 hydroxyphenylacetate 1 monooxygenaseIdentifiersEC no 1 14 13 18CAS no 55326 44 8DatabasesIntEnzIntEnz viewBRENDABRENDA entryExPASyNiceZyme viewKEGGKEGG entryMetaCycmetabolic pathwayPRIAMprofilePDB structuresRCSB PDB PDBe PDBsumGene OntologyAmiGO QuickGOSearchPMCarticlesPubMedarticlesNCBIproteins 4 hydroxyphenylacetate NAD P H H O2 displaystyle rightleftharpoons homogentisate NAD P H2OThe 5 substrates of this enzyme are 4 hydroxyphenylacetate NADH NADPH H and O2 whereas its 4 products are homogentisate NAD NADP and H2O This enzyme belongs to the family of oxidoreductases specifically those acting on paired donors with O2 as oxidant and incorporation or reduction of oxygen The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor and incorporation of one atom o oxygen into the other donor The systematic name of this enzyme class is 4 hydroxyphenylacetate NAD P H oxygen oxidoreductase 1 hydroxylating Other names in common use include 4 hydroxyphenylacetate 1 hydroxylase 4 hydroxyphenylacetic 1 hydroxylase and 4 HPA 1 hydroxylase This enzyme participates in tyrosine metabolism It employs one cofactor FAD References editHareland WA Crawford RL Chapman PJ Dagley S 1975 Metabolic function and properties of 4 hydroxyphenylacetic acid 1 hydroxylase from Pseudomonas acidovorans J Bacteriol 121 1 272 85 PMC 285641 PMID 234937 Portal nbsp Biology This EC 1 14 13 enzyme related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title 4 hydroxyphenylacetate 1 monooxygenase amp oldid 1172336531, wikipedia, wiki, book, books, library,

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