This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor, more specifically it is part of the group of hydroxysteroid dehydrogenases. The systematic name of this enzyme class is 3alpha-hydroxysteroid:NAD(P)+ oxidoreductase (A-specific).
Structural studiesedit
As of late 2007, 11 structures have been solved for this class of enzymes, with PDB accession codes 1J96, 1LWI, 1S1P, 1S1R, 1S2A, 1S2C, 1XJB, 2F38, 2FGB, 2HDJ, and 2IPJ.
Referencesedit
Bjorkhem I, Danielsson H (1970). "Stereochemistry of hydrogen transfer from pyridine nucleotides catalyzed by delta-4-3-oxosteroid 5-beta-reductase and 3-alpha-hydroxysteroid dehydrogenase from rat liver". Eur. J. Biochem. 12 (1): 80–4. doi:10.1111/j.1432-1033.1970.tb00823.x. PMID 4392180.
Tomkins GM (1956). "A mammalian 3alpha-hydroxysteroid dehydrogenase". J. Biol. Chem. 218 (1): 437–447. PMID 13278351.
3alpha, hydroxysteroid, dehydrogenase, specific, enzymology, enzyme, that, catalyzes, chemical, reaction3, alpha, hydroxysteroid, dehydrogenase, specific, identifiersec, 213databasesintenzintenz, viewbrendabrenda, entryexpasynicezyme, viewkeggkegg, entrymetacy. In enzymology a 3alpha hydroxysteroid dehydrogenase A specific EC 1 1 1 213 is an enzyme that catalyzes the chemical reaction3 alpha hydroxysteroid dehydrogenase A specific IdentifiersEC no 1 1 1 213DatabasesIntEnzIntEnz viewBRENDABRENDA entryExPASyNiceZyme viewKEGGKEGG entryMetaCycmetabolic pathwayPRIAMprofilePDB structuresRCSB PDB PDBe PDBsumGene OntologyAmiGO QuickGOSearchPMCarticlesPubMedarticlesNCBIproteins androsterone NAD P displaystyle rightleftharpoons 5alpha androstane 3 17 dione NAD P H H The 3 substrates of this enzyme are androsterone NAD and NADP whereas its 4 products are 5alpha androstane 3 17 dione NADH NADPH and H This enzyme belongs to the family of oxidoreductases specifically those acting on the CH OH group of donor with NAD or NADP as acceptor more specifically it is part of the group of hydroxysteroid dehydrogenases The systematic name of this enzyme class is 3alpha hydroxysteroid NAD P oxidoreductase A specific Structural studies editAs of late 2007 11 structures have been solved for this class of enzymes with PDB accession codes 1J96 1LWI 1S1P 1S1R 1S2A 1S2C 1XJB 2F38 2FGB 2HDJ and 2IPJ References editBjorkhem I Danielsson H 1970 Stereochemistry of hydrogen transfer from pyridine nucleotides catalyzed by delta 4 3 oxosteroid 5 beta reductase and 3 alpha hydroxysteroid dehydrogenase from rat liver Eur J Biochem 12 1 80 4 doi 10 1111 j 1432 1033 1970 tb00823 x PMID 4392180 Tomkins GM 1956 A mammalian 3alpha hydroxysteroid dehydrogenase J Biol Chem 218 1 437 447 PMID 13278351 Portal nbsp Biology This EC 1 1 1 enzyme related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title 3alpha hydroxysteroid dehydrogenase A specific amp oldid 1172371656, wikipedia, wiki, book, books, library,
