Thus, the two substrates of this enzyme are 3-hydroxyanthranilate and O2, whereas its product is 2-amino-3-carboxymuconate semialdehyde.
This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O2 as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O2.
The systematic name of this enzyme class is 3-hydroxyanthranilate:oxygen 3,4-oxidoreductase (decyclizing). Other names in common use include 3-hydroxyanthranilate oxygenase, 3-hydroxyanthranilic acid oxygenase, 3-hydroxyanthranilic oxygenase, 3-hydroxyanthranilic acid oxidase and 3HAO. This enzyme participates in tryptophan metabolism. It employs one cofactor, iron.
Structural studiesedit
As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes 1YFU, 1YFW, 1YFX, 1YFY, 1ZVF, and 2QNK.h
Referencesedit
DECKER RH, KANG HH, LEACH FR, HENDERSON LM (1961). "Purification and properties of 3-hydroxyanthranilic acid oxidase". J. Biol. Chem. 236 (11): 3076–82. doi:10.1016/S0021-9258(19)76432-1. PMID 13884755.
Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 8, Academic Press, New York, 1963, p. 353-371.
haao, hydroxyanthranilate, dioxygenase, enzyme, encoded, gene, that, catalyzes, chemical, reaction3, hydroxyanthranilic, acid, dioxygenaseidentifiersaliases3hydroanth, doaseipr0103293, hydroxyanthranilate, dioxygenase3, hydroxyanthranilate, oxygenase3, hydroxy. 3 hydroxyanthranilate 3 4 dioxygenase EC 1 13 11 6 is an enzyme encoded by the HAAO gene that catalyzes the chemical reaction3 hydroxyanthranilic acid dioxygenaseIdentifiersAliases3hydroanth dOaseIPR0103293 hydroxyanthranilate 3 4 dioxygenase3 hydroxyanthranilate oxygenase3 hydroxyanthranilic oxygenase3 hydroxyanthranilate oxygen 3 4 oxidoreductase decyclizing 3 hydroxyanthranilic acid oxygenaseExternal IDsGeneCards 1 OrthologsSpeciesHumanMouseEntrezn an aEnsembln an aUniProtnan aRefSeq mRNA n an aRefSeq protein n an aLocation UCSC n an aPubMed searchn an aWikidataView Edit Human3 hydroxyanthranilate 3 4 dioxygenase3 hydroxyanthranilate 3 4 dioxygenase monomer HumanIdentifiersEC no 1 13 11 6CAS no 9029 50 9DatabasesIntEnzIntEnz viewBRENDABRENDA entryExPASyNiceZyme viewKEGGKEGG entryMetaCycmetabolic pathwayPRIAMprofilePDB structuresRCSB PDB PDBe PDBsumGene OntologyAmiGO QuickGOSearchPMCarticlesPubMedarticlesNCBIproteins 3 hydroxyanthranilate O2 displaystyle rightleftharpoons 2 amino 3 carboxymuconate semialdehydeThus the two substrates of this enzyme are 3 hydroxyanthranilate and O2 whereas its product is 2 amino 3 carboxymuconate semialdehyde This enzyme belongs to the family of oxidoreductases specifically those acting on single donors with O2 as oxidant and incorporation of two atoms of oxygen into the substrate oxygenases The oxygen incorporated need not be derived from O2 The systematic name of this enzyme class is 3 hydroxyanthranilate oxygen 3 4 oxidoreductase decyclizing Other names in common use include 3 hydroxyanthranilate oxygenase 3 hydroxyanthranilic acid oxygenase 3 hydroxyanthranilic oxygenase 3 hydroxyanthranilic acid oxidase and 3HAO This enzyme participates in tryptophan metabolism It employs one cofactor iron Structural studies editAs of late 2007 6 structures have been solved for this class of enzymes with PDB accession codes 1YFU 1YFW 1YFX 1YFY 1ZVF and 2QNK hReferences editDECKER RH KANG HH LEACH FR HENDERSON LM 1961 Purification and properties of 3 hydroxyanthranilic acid oxidase J Biol Chem 236 11 3076 82 doi 10 1016 S0021 9258 19 76432 1 PMID 13884755 Boyer P D Lardy H and Myrback K Eds The Enzymes 2nd ed vol 8 Academic Press New York 1963 p 353 371 Portal nbsp Biology Retrieved from https en wikipedia org w index php title HAAO amp oldid 1172349419, wikipedia, wiki, book, books, library,
