GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-D-glucosaminyl-R GDP + beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D- glucosaminyl-R
Thus, the two substrates of this enzyme are GDP-beta-L-fucose and [[beta-D-galactosyl-(1->3)-N-acetyl-D-glucosaminyl-R]], whereas its 3 products are GDP, [[beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-]], and glucosaminyl-R.
This enzyme participates in 3 metabolic pathways: glycosphingolipid biosynthesis - lactoseries, glycosphingolipid biosynthesis - neo-lactoseries, and glycan structures - biosynthesis 2.
Nomenclatureedit
This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is GDP-L-fucose:3-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 4I-alpha-L-fucosyltransferase. Other names in common use include:
GDP-beta-L-fucose:3-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R, and 4I-alpha-L-fucosyltransferase.
Referencesedit
Prieels JP, Monnom D, Dolmans M, Beyer TA, Hill RL (October 1981). "Co-purification of the Lewis blood group N-acetylglucosaminide alpha 1 goes to 4 fucosyltransferase and an N-acetylglucosaminide alpha 1 goes to 3 fucosyltransferase from human milk". The Journal of Biological Chemistry. 256 (20): 10456–63. PMID 7287719.
Rasko DA, Wang G, Palcic MM, Taylor DE (February 2000). "Cloning and characterization of the alpha(1,3/4) fucosyltransferase of Helicobacter pylori". The Journal of Biological Chemistry. 275 (7): 4988–94. doi:10.1074/jbc.275.7.4988. PMID 10671538.
Wilson IB (June 2001). "Identification of a cDNA encoding a plant Lewis-type alpha1,4-fucosyltransferase". Glycoconjugate Journal. 18 (6): 439–47. doi:10.1023/A:1016030000527. PMID 12084979.
Ma B, Wang G, Palcic MM, Hazes B, Taylor DE (June 2003). "C-terminal amino acids of Helicobacter pylori alpha1,3/4 fucosyltransferases determine type I and type II transfer". The Journal of Biological Chemistry. 278 (24): 21893–900. doi:10.1074/jbc.M301704200. PMID 12676935.
galactosyl, acetylglucosaminide, alpha, fucosyltransferase, enzymology, galactosyl, acetylglucosaminide, alpha, fucosyltransferase, enzyme, that, catalyzes, chemical, reaction3, galactosyl, acetylglucosaminide, alpha, fucosyltransferaseidentifiersec, 65cas, 37. In enzymology a 3 galactosyl N acetylglucosaminide 4 alpha L fucosyltransferase EC 2 4 1 65 is an enzyme that catalyzes the chemical reaction3 galactosyl N acetylglucosaminide 4 alpha L fucosyltransferaseIdentifiersEC no 2 4 1 65CAS no 37277 69 3DatabasesIntEnzIntEnz viewBRENDABRENDA entryExPASyNiceZyme viewKEGGKEGG entryMetaCycmetabolic pathwayPRIAMprofilePDB structuresRCSB PDB PDBe PDBsumGene OntologyAmiGO QuickGOSearchPMCarticlesPubMedarticlesNCBIproteins GDP beta L fucose beta D galactosyl 1 gt 3 N acetyl D glucosaminyl R displaystyle rightleftharpoons GDP beta D galactosyl 1 gt 3 alpha L fucosyl 1 gt 4 N acetyl beta D glucosaminyl RThus the two substrates of this enzyme are GDP beta L fucose and beta D galactosyl 1 gt 3 N acetyl D glucosaminyl R whereas its 3 products are GDP beta D galactosyl 1 gt 3 alpha L fucosyl 1 gt 4 N acetyl beta D and glucosaminyl R This enzyme participates in 3 metabolic pathways glycosphingolipid biosynthesis lactoseries glycosphingolipid biosynthesis neo lactoseries and glycan structures biosynthesis 2 Nomenclature editThis enzyme belongs to the family of glycosyltransferases specifically the hexosyltransferases The systematic name of this enzyme class is GDP L fucose 3 beta D galactosyl N acetyl D glucosaminyl R 4I alpha L fucosyltransferase Other names in common use include Lea dependent alpha 3 4 fucosyltransferase alpha 1 3 1 4 fucosyltransferase III alpha 1 gt 4 L fucosyltransferase alpha 4 L fucosyltransferase beta acetylglucosaminylsaccharide fucosyltransferase FucT II Lewis alpha 1 gt 3 4 fucosyltransferase Lewis blood group alpha 1 gt 3 4 fucosyltransferase Lewis Le blood group gene dependent alpha 1 gt 3 4 L fucosyltransferase blood group Lewis alpha 4 fucosyltransferase blood group substance Lea dependent fucosyltransferase guanosine diphosphofucose beta acetylglucosaminylsaccharide 4 alpha L fucosyltransferase guanosine diphosphofucose glycoprotein 4 alpha L fucosyltransferase guanosine diphosphofucose glycoprotein 4 alpha fucosyltransferase 3 alpha galactosyl N acetylglucosaminide 4 alpha L fucosyltransferase GDP beta L fucose 3 beta D galactosyl N acetyl D glucosaminyl R and 4I alpha L fucosyltransferase References editPrieels JP Monnom D Dolmans M Beyer TA Hill RL October 1981 Co purification of the Lewis blood group N acetylglucosaminide alpha 1 goes to 4 fucosyltransferase and an N acetylglucosaminide alpha 1 goes to 3 fucosyltransferase from human milk The Journal of Biological Chemistry 256 20 10456 63 PMID 7287719 Rasko DA Wang G Palcic MM Taylor DE February 2000 Cloning and characterization of the alpha 1 3 4 fucosyltransferase of Helicobacter pylori The Journal of Biological Chemistry 275 7 4988 94 doi 10 1074 jbc 275 7 4988 PMID 10671538 Wilson IB June 2001 Identification of a cDNA encoding a plant Lewis type alpha1 4 fucosyltransferase Glycoconjugate Journal 18 6 439 47 doi 10 1023 A 1016030000527 PMID 12084979 Ma B Wang G Palcic MM Hazes B Taylor DE June 2003 C terminal amino acids of Helicobacter pylori alpha1 3 4 fucosyltransferases determine type I and type II transfer The Journal of Biological Chemistry 278 24 21893 900 doi 10 1074 jbc M301704200 PMID 12676935 Portal nbsp Biology This EC 2 4 enzyme related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title 3 Galactosyl N acetylglucosaminide 4 alpha L fucosyltransferase amp oldid 1172335624, wikipedia, wiki, book, books, library,
