23S rRNA (pseudouridine1915-N3)-methyltransferase

23S rRNA (pseudouridine¹⁹¹⁵-N³)-methyltransferase (EC 2.1.1.177, YbeA, RlmH, pseudouridine methyltransferase, m3Psi methyltransferase, Psi1915-specific methyltransferase, rRNA large subunit methyltransferase H) is an enzyme with systematic name S-adenosyl-L-methionine:23S rRNA (pseudouridine¹⁹¹⁵-N³)-methyltransferase.^[1][2] This enzyme catalyses the following chemical reaction

23S rRNA (pseudouridine^1915-N^3)-methyltransferase
Identifiers
EC no.	2.1.1.177
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

S-adenosyl-L-methionine + pseudouridine¹⁹¹⁵ in 23S rRNA ${\displaystyle \rightleftharpoons }$ S-adenosyl-L-homocysteine + N³-methylpseudouridine¹⁹¹⁵ in 23S rRNA

YbeA does not methylate uridine at position 1915.

References

1. Ero R, Peil L, Liiv A, Remme J (October 2008). "Identification of pseudouridine methyltransferase in Escherichia coli". RNA. 14 (10): 2223–33. doi:10.1261/rna.1186608. PMC 2553739. PMID 18755836.
2. Purta E, Kaminska KH, Kasprzak JM, Bujnicki JM, Douthwaite S (October 2008). "YbeA is the m3Psi methyltransferase RlmH that targets nucleotide 1915 in 23S rRNA". RNA. 14 (10): 2234–44. doi:10.1261/rna.1198108. PMC 2553730. PMID 18755835.

External links

• 23S+rRNA+(pseudouridine1915-N3)-methyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)