Wikipedia
2-Coumarate reductase
In enzymology, a 2-coumarate reductase or melilotate dehydrogenase (EC 1.3.1.11) is an enzyme that catalyzes the chemical reaction
| 2-coumarate reductase | |
|---|---|
| Identifiers | |
| EC no. | 1.3.1.11 |
| CAS no. | 37251-10-8 |
| Databases | |
| IntEnz | IntEnz view |
| BRENDA | BRENDA entry |
| ExPASy | NiceZyme view |
| KEGG | KEGG entry |
| MetaCyc | metabolic pathway |
| PRIAM | profile |
| PDB structures | RCSB PDB PDBe PDBsum |
| Gene Ontology | AmiGO / QuickGO |
- 3-(2-hydroxyphenyl)propanoate + NAD+ 2-coumarate + NADH + H+
Thus, the two substrates of this enzyme are 3-(2-hydroxyphenyl)propanoate and NAD+, whereas its 3 products are 2-coumarate, NADH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 3-(2-hydroxyphenyl)propanoate:NAD+ oxidoreductase. This enzyme participates in phenylalanine metabolism.
References edit
- Levy CC, Weinstein GD (December 1964). "The metabolism of coumarin by a microorganism. II. The reduction of o-coumaric acid to melilotic acid". Biochemistry. 3 (12): 1944–7. doi:10.1021/bi00900a027. PMID 14269315.