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1-acylglycerol-3-phosphate O-acyltransferase

In enzymology, a 1-acylglycerol-3-phosphate O-acyltransferase (EC 2.3.1.51) is an enzyme that catalyzes the chemical reaction

1-acylglycerol-3-phosphate O-acyltransferase
Identifiers
EC no.2.3.1.51
CAS no.51901-16-7
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins
acyl-CoA + 1-acyl-sn-glycerol 3-phosphate CoA + 1,2-diacyl-sn-glycerol 3-phosphate

Thus, the two substrates of this enzyme are acyl-CoA and 1-acyl-sn-glycerol 3-phosphate, whereas its two products are CoA and 1,2-diacyl-sn-glycerol 3-phosphate.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase. Other names in common use include 1-acyl-sn-glycero-3-phosphate acyltransferase, 1-acyl-sn-glycerol 3-phosphate acyltransferase, 1-acylglycero-3-phosphate acyltransferase, 1-acylglycerolphosphate acyltransferase, 1-acylglycerophosphate acyltransferase, and lysophosphatidic acid-acyltransferase. This enzyme participates in 3 metabolic pathways: glycerolipid metabolism, glycerophospholipid metabolism, and ether lipid metabolism.

References edit

  • Frentzen M, Heinz E, McKeon TA, Stumpf PK (1983). "Specificities and selectivities of glycerol-3-phosphate acyltransferase and monoacylglycerol-3-phosphate acyltransferase from pea and spinach chloroplasts". Eur. J. Biochem. 129 (3): 629–636. doi:10.1111/j.1432-1033.1983.tb07096.x. PMID 6825679.
  • Hill EE, Lands WE (1968). "Incorporation of long-chain and polyunsaturated acids into phosphatidate and phosphatidylcholine" (PDF). Biochim. Biophys. Acta. 152 (3): 645–8. doi:10.1016/0005-2760(68)90109-4. hdl:2027.42/33183. PMID 5661029.
  • Yamashita S, Hosaka K, Numa S (1973). "Acyl-donor specificities of partially purified 1-acylglycerophosphate acyltransferase, 2-acylglycerophosphate acyltransferase and 1-acylglycerophosphorylcholine acyltransferase from rat-liver microsomes". Eur. J. Biochem. 38 (1): 25–31. doi:10.1111/j.1432-1033.1973.tb03028.x. PMID 4774123.


acylglycerol, phosphate, acyltransferase, enzymology, enzyme, that, catalyzes, chemical, reactionidentifiersec, 51cas, 51901, 7databasesintenzintenz, viewbrendabrenda, entryexpasynicezyme, viewkeggkegg, entrymetacycmetabolic, pathwaypriamprofilepdb, structures. In enzymology a 1 acylglycerol 3 phosphate O acyltransferase EC 2 3 1 51 is an enzyme that catalyzes the chemical reaction1 acylglycerol 3 phosphate O acyltransferaseIdentifiersEC no 2 3 1 51CAS no 51901 16 7DatabasesIntEnzIntEnz viewBRENDABRENDA entryExPASyNiceZyme viewKEGGKEGG entryMetaCycmetabolic pathwayPRIAMprofilePDB structuresRCSB PDB PDBe PDBsumGene OntologyAmiGO QuickGOSearchPMCarticlesPubMedarticlesNCBIproteins acyl CoA 1 acyl sn glycerol 3 phosphate displaystyle rightleftharpoons CoA 1 2 diacyl sn glycerol 3 phosphateThus the two substrates of this enzyme are acyl CoA and 1 acyl sn glycerol 3 phosphate whereas its two products are CoA and 1 2 diacyl sn glycerol 3 phosphate This enzyme belongs to the family of transferases specifically those acyltransferases transferring groups other than aminoacyl groups The systematic name of this enzyme class is acyl CoA 1 acyl sn glycerol 3 phosphate 2 O acyltransferase Other names in common use include 1 acyl sn glycero 3 phosphate acyltransferase 1 acyl sn glycerol 3 phosphate acyltransferase 1 acylglycero 3 phosphate acyltransferase 1 acylglycerolphosphate acyltransferase 1 acylglycerophosphate acyltransferase and lysophosphatidic acid acyltransferase This enzyme participates in 3 metabolic pathways glycerolipid metabolism glycerophospholipid metabolism and ether lipid metabolism References editFrentzen M Heinz E McKeon TA Stumpf PK 1983 Specificities and selectivities of glycerol 3 phosphate acyltransferase and monoacylglycerol 3 phosphate acyltransferase from pea and spinach chloroplasts Eur J Biochem 129 3 629 636 doi 10 1111 j 1432 1033 1983 tb07096 x PMID 6825679 Hill EE Lands WE 1968 Incorporation of long chain and polyunsaturated acids into phosphatidate and phosphatidylcholine PDF Biochim Biophys Acta 152 3 645 8 doi 10 1016 0005 2760 68 90109 4 hdl 2027 42 33183 PMID 5661029 Yamashita S Hosaka K Numa S 1973 Acyl donor specificities of partially purified 1 acylglycerophosphate acyltransferase 2 acylglycerophosphate acyltransferase and 1 acylglycerophosphorylcholine acyltransferase from rat liver microsomes Eur J Biochem 38 1 25 31 doi 10 1111 j 1432 1033 1973 tb03028 x PMID 4774123 Portal nbsp Biology This EC 2 3 enzyme related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title 1 acylglycerol 3 phosphate O acyltransferase amp oldid 1172334176, wikipedia, wiki, book, books, library,

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