This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:[acyl-carrier-protein] S-acetyltransferase. Other names in common use include acetyl coenzyme A-acyl-carrier-protein transacylase, Acetyl CoA:ACP transacylase, [acyl-carrier-protein]acetyltransferase, [ACP]acetyltransferase, and ACAT. This enzyme participates in fatty acid biosynthesis.
Structural studiesedit
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2PFF.
Referencesedit
Prescott DJ, Vagelos PR (1972). "Acyl carrier protein". Advances in Enzymology and Related Areas of Molecular Biology. Advances in Enzymology - and Related Areas of Molecular Biology. Vol. 36. pp. 269–311. doi:10.1002/9780470122815.ch8. ISBN9780470122815. PMID 4561013.
Vance DE, Mitsuhashi O, Bloch K (1973). "Purification and properties of the fatty acid synthetase from Mycobacterium phlei". J. Biol. Chem. 248 (7): 2303–9. PMID 4698221.
Williamson IP, Wakil SJ (1966). "Studies on the mechanism of fatty acid synthesis. XVII. Preparation and general properties of acetyl coenzyme A and malonyl coenzyme A-acyl carrier protein transacylases". J. Biol. Chem. 241 (10): 2326–32. PMID 5330116.
Lowe PN, Rhodes S (1988). "Purification and characterization of acyl-carrier-protein acetyltransferase from Escherichia coli". Biochem. J. 250 (3): 789–96. doi:10.1042/bj2500789. PMC1148925. PMID 3291856.
Tsay JT, Oh W, Larson TJ, Jackowski S, Rock CO (1992). "Isolation and characterization of the beta-ketoacyl-acyl carrier protein synthase III gene (fabH) from Escherichia coli K-12". J. Biol. Chem. 267 (10): 6807–14. PMID 1551888.
Rangan VS, Smith S (1997). "Alteration of the substrate specificity of the malonyl-CoA/acetyl-CoA:acyl carrier protein S-acyltransferase domain of the multifunctional fatty acid synthase by mutation of a single arginine residue". J. Biol. Chem. 272 (18): 11975–8. doi:10.1074/jbc.272.18.11975. PMID 9115261.
acyl, carrier, protein, acetyltransferase, enzymology, acyl, carrier, protein, acetyltransferase, enzyme, that, catalyzes, reversible, chemical, reaction, acyl, carrier, protein, acetyltransferaseidentifiersec, 38cas, 37257, 2databasesintenzintenz, viewbrendab. In enzymology a acyl carrier protein S acetyltransferase EC 2 3 1 38 is an enzyme that catalyzes the reversible chemical reaction acyl carrier protein S acetyltransferaseIdentifiersEC no 2 3 1 38CAS no 37257 16 2DatabasesIntEnzIntEnz viewBRENDABRENDA entryExPASyNiceZyme viewKEGGKEGG entryMetaCycmetabolic pathwayPRIAMprofilePDB structuresRCSB PDB PDBe PDBsumGene OntologyAmiGO QuickGOSearchPMCarticlesPubMedarticlesNCBIproteins acetyl CoA acyl carrier protein displaystyle rightleftharpoons CoA acetyl acyl carrier protein Thus the two substrates of this enzyme are acetyl CoA and acyl carrier protein whereas its two products are CoA and acetyl acyl carrier protein This enzyme belongs to the family of transferases specifically those acyltransferases transferring groups other than aminoacyl groups The systematic name of this enzyme class is acetyl CoA acyl carrier protein S acetyltransferase Other names in common use include acetyl coenzyme A acyl carrier protein transacylase Acetyl CoA ACP transacylase acyl carrier protein acetyltransferase ACP acetyltransferase and ACAT This enzyme participates in fatty acid biosynthesis Structural studies editAs of late 2007 only one structure has been solved for this class of enzymes with the PDB accession code 2PFF References editPrescott DJ Vagelos PR 1972 Acyl carrier protein Advances in Enzymology and Related Areas of Molecular Biology Advances in Enzymology and Related Areas of Molecular Biology Vol 36 pp 269 311 doi 10 1002 9780470122815 ch8 ISBN 9780470122815 PMID 4561013 Vance DE Mitsuhashi O Bloch K 1973 Purification and properties of the fatty acid synthetase from Mycobacterium phlei J Biol Chem 248 7 2303 9 PMID 4698221 Williamson IP Wakil SJ 1966 Studies on the mechanism of fatty acid synthesis XVII Preparation and general properties of acetyl coenzyme A and malonyl coenzyme A acyl carrier protein transacylases J Biol Chem 241 10 2326 32 PMID 5330116 Lowe PN Rhodes S 1988 Purification and characterization of acyl carrier protein acetyltransferase from Escherichia coli Biochem J 250 3 789 96 doi 10 1042 bj2500789 PMC 1148925 PMID 3291856 Tsay JT Oh W Larson TJ Jackowski S Rock CO 1992 Isolation and characterization of the beta ketoacyl acyl carrier protein synthase III gene fabH from Escherichia coli K 12 J Biol Chem 267 10 6807 14 PMID 1551888 Rangan VS Smith S 1997 Alteration of the substrate specificity of the malonyl CoA acetyl CoA acyl carrier protein S acyltransferase domain of the multifunctional fatty acid synthase by mutation of a single arginine residue J Biol Chem 272 18 11975 8 doi 10 1074 jbc 272 18 11975 PMID 9115261 Portal nbsp Biology This EC 2 3 enzyme related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title acyl carrier protein S acetyltransferase amp oldid 1172333609, wikipedia, wiki, book, books, library,
