Gale was born in Liverpool and grew up in Woolton attending Gateacre Community Comprehensive School.[3] He moved to Wadham College, University of Oxford, where he received his B.A. (Hons) degree in 1992 (M.A. Oxon. 1995) then moving in October 1992 to Linacre College where he graduated with a D.Phil. degree in 1995. He then moved to the University of Texas at Austin as a Fulbright Scholar with Prof. Jonathan Sessler. He returned to Oxford in 1997 as a Royal Society University Research Fellow and moved to a lectureship at the University of Southampton in 1999. He was promoted to a personal chair in supramolecular chemistry in 2007 and served as Head of Chemistry at the University of Southampton between 2010 and 2016. He was awarded a Doctor of Science degree by the University of Oxford in 2014. In January 2017 he moved to the University of Sydney where he took up the role of Head of the School of Chemistry[4] and in 2020 Associate Dean (International) in the Faculty of Science. He is currently Interim Executive Dean of the Faculty of Science at the University of Sydney serving from April 2022 to January 2023.
Gale's research interests are in supramolecular chemistry and in particular the molecular recognition and transmembrane transport of anions. His early work concerned the design of structurally simple anion receptors and elucidating other processes such as proton transfer that often accompany anion complexation.[5] More recent research has focused on transmembrane anion transport. Gale has designed and synthesised a variety of highly effective classes of anion transporters including tren-based tris-ureas and -thioureas,[6] squaramides[7] and ortho-phenylene-based bis ureas.[8] In 2013 Gale and co-workers published a quantitative structure activity relationship study showing that in a series of simple thioureas with one n-hexyl substituent and a phenyl substituent with different groups in the 4-position, the lipophilicity of the receptor is the dominant molecular parameter determining effective transport, with smaller contributions from the receptors’ volume and affinity for chloride.[9]
Very recent work has focused on the design of new assays to measure anion transport[10] and the development of selective transporters.[11][12] Gale is notable for his work at the interface of supramolecular and medicinal chemistry showing the effect that anionophores developed in his research group have on biological systems. This includes restoring the flux of chloride through epithelial cell membranes (with potential future application as a channel replacement therapy in cystic fibrosis)[13][14] and causing cell death in cancer cells by triggering apoptosis and interfering with autophagy.[15][16]
Other aspects of Gale's work on transmembrane transport include the first synthetic chloride pumping system that uses fatty acids as fuels to create a chloride gradient across a lipid bilayer membrane,[17] and the development of anion transporters that can be switched by membrane potential gradients[18] or by the presence of reducing agents found in higher concentrations in tumours than in healthy tissue.[19]
Gale is listed as a Thomson Reuters/Clarivate Analytics Highly Cited Research in Chemistry[20] and has received a number of awards for his research including the RSC Bob Hay Lectureship in 2004,[21] RSC Corday-Morgan Prize in 2005, a 2013 Royal Society Wolfson Research Merit Award, RSC Supramolecular Chemistry Award in 2014[22] and the International Izatt-Christensen Award in Macrocyclic and Supramolecular Chemistry in 2018.[23] In 2020 he was awarded a University of Sydney Vice-Chancellor’s Excellence Award for Outstanding Research[24] and was highlighted by The Australian newspaper Research supplement (23 September 2020) as an Australian Field Research Leader (Chemistry & Material Sciences (general)).[25]
Gale is the editor-in-chief of Coordination Chemistry Reviews[26] and the co-editor-in-chief of Supramolecular Chemistry.[27]
References
^Science, Faculty of. "Faculty of Science staff - University of Sydney". sydney.edu.au.
^Busschaert, Nathalie; Caltagirone, Claudia; Van Rossom, Wim; Gale, Philip A. (12 August 2015). "Applications of Supramolecular Anion Recognition". Chemical Reviews. 115 (15): 8038–8155. doi:10.1021/acs.chemrev.5b00099. PMID 25996028.
^Gale, Philip A. (1 July 2006). "Structural and Molecular Recognition Studies with Acyclic Anion Receptors". Accounts of Chemical Research. 39 (7): 465–475. doi:10.1021/ar040237q. PMID 16846210.
^Busschaert, Nathalie; Wenzel, Marco; Light, Mark E.; Iglesias-Hernández, Paulina; Pérez-Tomás, Ricardo; Gale, Philip A. (7 September 2011). "Structure–Activity Relationships in Tripodal Transmembrane Anion Transporters: The Effect of Fluorination". Journal of the American Chemical Society. 133 (35): 14136–14148. doi:10.1021/ja205884y. PMC3436094. PMID 21846096.
^Busschaert, Nathalie; Kirby, Isabelle L.; Young, Sarah; Coles, Simon J.; Horton, Peter N.; Light, Mark E.; Gale, Philip A. (27 April 2012). "Squaramides as Potent Transmembrane Anion Transporters". Angewandte Chemie International Edition. 51 (18): 4426–4430. doi:10.1002/anie.201200729. PMID 22461434. S2CID 34164978.
^Karagiannidis, Louise E.; Haynes, Cally J. E.; Holder, Katie J.; Kirby, Isabelle L.; Moore, Stephen J.; Wells, Neil J.; Gale, Philip A. (16 September 2014). "Highly effective yet simple transmembrane anion transporters based upon ortho-phenylenediamine bis-ureas". Chemical Communications. 50 (81): 12050–12053. doi:10.1039/C4CC05519E. PMID 25178589.
^Busschaert, Nathalie; Bradberry, Samuel J.; Wenzel, Marco; Haynes, Cally J. E.; Hiscock, Jennifer R.; Kirby, Isabelle L.; Karagiannidis, Louise E.; Moore, Stephen J.; Wells, Neil J.; Herniman, Julie; Langley, G. John; Horton, Peter N.; Light, Mark E.; Marques, Igor; Costa, Paulo J.; Félix, Vítor; Frey, Jeremy G.; Gale, Philip A. (2 July 2013). "Towards predictable transmembrane transport: QSAR analysis of anion binding and transport". Chemical Science. 4 (8): 3036–3045. doi:10.1039/C3SC51023A. hdl:10773/19223. S2CID 95013961.
^Wu, Xin; Howe, Ethan N. W.; Gale, Philip A. (21 August 2018). "Supramolecular Transmembrane Anion Transport: New Assays and Insights". Accounts of Chemical Research. 51 (8): 1870–1879. doi:10.1021/acs.accounts.8b00264. hdl:2123/24729. PMID 30063324. S2CID 51890600.
^Wu, Xin; Gale, Philip A. (2021). "Measuring anion transport selectivity: a cautionary tale". Chemical Communications. 57 (33): 3979–3982. doi:10.1039/D1CC01038G. PMID 33885701. S2CID 233349341.
^Wu, Xin; Judd, Luke W.; Howe, Ethan N.W.; Withecombe, Anne M.; Soto-Cerrato, Vanessa; Li, Hongyu; Busschaert, Nathalie; Valkenier, Hennie; Pérez-Tomás, Ricardo; Sheppard, David N.; Jiang, Yun-Bao; Davis, Anthony P.; Gale, Philip A. (July 2016). "Nonprotonophoric Electrogenic Cl − Transport Mediated by Valinomycin-like Carriers". Chem. 1 (1): 127–146. doi:10.1016/j.chempr.2016.04.002.
^Spooner, Michael J.; Li, Hongyu; Marques, Igor; Costa, Pedro M. R.; Wu, Xin; Howe, Ethan N. W.; Busschaert, Nathalie; Moore, Stephen J.; Light, Mark E.; Sheppard, David N.; Félix, Vítor; Gale, Philip A. (2019). "Fluorinated synthetic anion carriers: experimental and computational insights into transmembrane chloride transport". Chemical Science. 10 (7): 1976–1985. doi:10.1039/C8SC05155K. PMC6381411. PMID 30881627.
^Li, Hongyu; Valkenier, Hennie; Thorne, Abigail G.; Dias, Christopher M.; Cooper, James A.; Kieffer, Marion; Busschaert, Nathalie; Gale, Philip A.; Sheppard, David N.; Davis, Anthony P. (2019). "Anion carriers as potential treatments for cystic fibrosis: transport in cystic fibrosis cells, and additivity to channel-targeting drugs". Chemical Science. 10 (42): 9663–9672. doi:10.1039/C9SC04242C. PMC6984391. PMID 32055336.
^Busschaert, Nathalie; Park, Seong-Hyun; Baek, Kyung-Hwa; Choi, Yoon Pyo; Park, Jinhong; Howe, Ethan N. W.; Hiscock, Jennifer R.; Karagiannidis, Louise E.; Marques, Igor; Félix, Vítor; Namkung, Wan; Sessler, Jonathan L.; Gale, Philip A.; Shin, Injae (July 2017). "A synthetic ion transporter that disrupts autophagy and induces apoptosis by perturbing cellular chloride concentrations". Nature Chemistry. 9 (7): 667–675. Bibcode:2017NatCh...9..667B. doi:10.1038/nchem.2706. PMC5648535. PMID 28644464.
^Park, Sang-Hyun; Park, Seong-Hyun; Howe, Ethan N.W.; Hyun, Ji Young; Chen, Li-Jun; Hwang, Inhong; Vargas-Zuñiga, Gabriela; Busschaert, Nathalie; Gale, Philip A.; Sessler, Jonathan L.; Shin, Injae (August 2019). "Determinants of Ion-Transporter Cancer Cell Death". Chem. 5 (8): 2079–2098. doi:10.1016/j.chempr.2019.05.001. PMC8009298. PMID 33791443.
^Howe, Ethan N. W.; Gale, Philip A. (10 July 2019). "Fatty Acid Fueled Transmembrane Chloride Transport". Journal of the American Chemical Society. 141 (27): 10654–10660. doi:10.1021/jacs.9b02116. PMID 31244178. S2CID 195695655.
^Wu, Xin; Small, Jennifer R.; Cataldo, Alessio; Withecombe, Anne M.; Turner, Peter; Gale, Philip A. (14 October 2019). "Voltage‐Switchable HCl Transport Enabled by Lipid Headgroup–Transporter Interactions". Angewandte Chemie International Edition. 58 (42): 15142–15147. doi:10.1002/anie.201907466. PMID 31400024. S2CID 199519085.
^Fares, Mohamed; Wu, Xin; Ramesh, Deepthi; Lewis, William; Keller, Paul A.; Howe, Ethan N. W.; Pérez‐Tomás, Ricardo; Gale, Philip A. (28 September 2020). "Stimuli‐Responsive Cycloaurated 'OFF‐ON' Switchable Anion Transporters". Angewandte Chemie International Edition. 59 (40): 17614–17621. doi:10.1002/anie.202006392. hdl:2123/23683. PMID 32583552. S2CID 220059631.
^. clarivate.com. Archived from the original on 2019-02-20. Retrieved 2020-05-05.
^"Supramolecular Chemistry Award 2014 Winner". www.rsc.org.
^"Ryoji Noyori ACES Award: M. G. Banwell / Liebig Memorial Medal: W. Schnick / Izatt-Christensen Award: P. A. Gale / Cram Lehn Pedersen Prize: R. Klajn". Angewandte Chemie International Edition. 57 (38): 12210. 17 September 2018. doi:10.1002/anie.201809044. S2CID 52018834.
^Gale, Philip A.; Gibb, Bruce C.; Coles, Simon J. "Supramolecular Chemistry". {{cite journal}}: Cite journal requires |journal= (help)
January 07, 2023
philip, gale, philip, alan, gale, born, 1969, british, chemist, professor, chemistry, school, chemistry, university, sydney, notable, work, supramolecular, chemistry, anions, gale, july, 2016born1969, liverpool, lancashire, uknationalitybritishawardsrsc, lectu. Philip Alan Gale born 1969 is a British chemist and Professor of Chemistry at the School of Chemistry University of Sydney 1 He is notable for his work on the supramolecular chemistry of anions 2 Philip A GaleGale in July 2016Born1969 age 53 54 Liverpool Lancashire UKNationalityBritishAwardsRSC Bob Hay Lectureship 2004 Corday Morgan Prize 2005 Royal Society Wolfson Research Merit Award 2013 Supramolecular Chemistry Award 2014 Izatt Christensen Award 2018 University of Sydney Vice Chancellor s Excellence Award for Outstanding Research 2020 Scientific careerFieldsSupramolecular chemistryInstitutionsUniversity of Sydney University of Southampton Wadham College University of Oxford Linacre College University of Oxford University of Texas at AustinGale was born in Liverpool and grew up in Woolton attending Gateacre Community Comprehensive School 3 He moved to Wadham College University of Oxford where he received his B A Hons degree in 1992 M A Oxon 1995 then moving in October 1992 to Linacre College where he graduated with a D Phil degree in 1995 He then moved to the University of Texas at Austin as a Fulbright Scholar with Prof Jonathan Sessler He returned to Oxford in 1997 as a Royal Society University Research Fellow and moved to a lectureship at the University of Southampton in 1999 He was promoted to a personal chair in supramolecular chemistry in 2007 and served as Head of Chemistry at the University of Southampton between 2010 and 2016 He was awarded a Doctor of Science degree by the University of Oxford in 2014 In January 2017 he moved to the University of Sydney where he took up the role of Head of the School of Chemistry 4 and in 2020 Associate Dean International in the Faculty of Science He is currently Interim Executive Dean of the Faculty of Science at the University of Sydney serving from April 2022 to January 2023 Gale s research interests are in supramolecular chemistry and in particular the molecular recognition and transmembrane transport of anions His early work concerned the design of structurally simple anion receptors and elucidating other processes such as proton transfer that often accompany anion complexation 5 More recent research has focused on transmembrane anion transport Gale has designed and synthesised a variety of highly effective classes of anion transporters including tren based tris ureas and thioureas 6 squaramides 7 and ortho phenylene based bis ureas 8 In 2013 Gale and co workers published a quantitative structure activity relationship study showing that in a series of simple thioureas with one n hexyl substituent and a phenyl substituent with different groups in the 4 position the lipophilicity of the receptor is the dominant molecular parameter determining effective transport with smaller contributions from the receptors volume and affinity for chloride 9 Very recent work has focused on the design of new assays to measure anion transport 10 and the development of selective transporters 11 12 Gale is notable for his work at the interface of supramolecular and medicinal chemistry showing the effect that anionophores developed in his research group have on biological systems This includes restoring the flux of chloride through epithelial cell membranes with potential future application as a channel replacement therapy in cystic fibrosis 13 14 and causing cell death in cancer cells by triggering apoptosis and interfering with autophagy 15 16 Other aspects of Gale s work on transmembrane transport include the first synthetic chloride pumping system that uses fatty acids as fuels to create a chloride gradient across a lipid bilayer membrane 17 and the development of anion transporters that can be switched by membrane potential gradients 18 or by the presence of reducing agents found in higher concentrations in tumours than in healthy tissue 19 Gale is listed as a Thomson Reuters Clarivate Analytics Highly Cited Research in Chemistry 20 and has received a number of awards for his research including the RSC Bob Hay Lectureship in 2004 21 RSC Corday Morgan Prize in 2005 a 2013 Royal Society Wolfson Research Merit Award RSC Supramolecular Chemistry Award in 2014 22 and the International Izatt Christensen Award in Macrocyclic and Supramolecular Chemistry in 2018 23 In 2020 he was awarded a University of Sydney Vice Chancellor s Excellence Award for Outstanding Research 24 and was highlighted by The Australian newspaper Research supplement 23 September 2020 as an Australian Field Research Leader Chemistry amp Material Sciences general 25 Gale is the editor in chief of Coordination Chemistry Reviews 26 and the co editor in chief of Supramolecular Chemistry 27 References Edit Science Faculty of Faculty of Science staff University of Sydney sydney edu au Gale Philip A Howe Ethan N W Wu Xin September 2016 Anion Receptor Chemistry Chem 1 3 351 422 doi 10 1016 j chempr 2016 08 004 Busschaert Nathalie Caltagirone Claudia Van Rossom Wim Gale Philip A 12 August 2015 Applications of Supramolecular Anion Recognition Chemical Reviews 115 15 8038 8155 doi 10 1021 acs chemrev 5b00099 PMID 25996028 P A Gale www journals elsevier com Gale Philip A 1 July 2006 Structural and Molecular Recognition Studies with Acyclic Anion Receptors Accounts of Chemical Research 39 7 465 475 doi 10 1021 ar040237q PMID 16846210 Busschaert Nathalie Wenzel Marco Light Mark E Iglesias Hernandez Paulina Perez Tomas Ricardo Gale Philip A 7 September 2011 Structure Activity Relationships in Tripodal Transmembrane Anion Transporters The Effect of Fluorination Journal of the American Chemical Society 133 35 14136 14148 doi 10 1021 ja205884y PMC 3436094 PMID 21846096 Busschaert Nathalie Kirby Isabelle L Young Sarah Coles Simon J Horton Peter N Light Mark E Gale Philip A 27 April 2012 Squaramides as Potent Transmembrane Anion Transporters Angewandte Chemie International Edition 51 18 4426 4430 doi 10 1002 anie 201200729 PMID 22461434 S2CID 34164978 Karagiannidis Louise E Haynes Cally J E Holder Katie J Kirby Isabelle L Moore Stephen J Wells Neil J Gale Philip A 16 September 2014 Highly effective yet simple transmembrane anion transporters based upon ortho phenylenediamine bis ureas Chemical Communications 50 81 12050 12053 doi 10 1039 C4CC05519E PMID 25178589 Busschaert Nathalie Bradberry Samuel J Wenzel Marco Haynes Cally J E Hiscock Jennifer R Kirby Isabelle L Karagiannidis Louise E Moore Stephen J Wells Neil J Herniman Julie Langley G John Horton Peter N Light Mark E Marques Igor Costa Paulo J Felix Vitor Frey Jeremy G Gale Philip A 2 July 2013 Towards predictable transmembrane transport QSAR analysis of anion binding and transport Chemical Science 4 8 3036 3045 doi 10 1039 C3SC51023A hdl 10773 19223 S2CID 95013961 Wu Xin Howe Ethan N W Gale Philip A 21 August 2018 Supramolecular Transmembrane Anion Transport New Assays and Insights Accounts of Chemical Research 51 8 1870 1879 doi 10 1021 acs accounts 8b00264 hdl 2123 24729 PMID 30063324 S2CID 51890600 Wu Xin Gale Philip A 2021 Measuring anion transport selectivity a cautionary tale Chemical Communications 57 33 3979 3982 doi 10 1039 D1CC01038G PMID 33885701 S2CID 233349341 Wu Xin Judd Luke W Howe Ethan N W Withecombe Anne M Soto Cerrato Vanessa Li Hongyu Busschaert Nathalie Valkenier Hennie Perez Tomas Ricardo Sheppard David N Jiang Yun Bao Davis Anthony P Gale Philip A July 2016 Nonprotonophoric Electrogenic Cl Transport Mediated by Valinomycin like Carriers Chem 1 1 127 146 doi 10 1016 j chempr 2016 04 002 Spooner Michael J Li Hongyu Marques Igor Costa Pedro M R Wu Xin Howe Ethan N W Busschaert Nathalie Moore Stephen J Light Mark E Sheppard David N Felix Vitor Gale Philip A 2019 Fluorinated synthetic anion carriers experimental and computational insights into transmembrane chloride transport Chemical Science 10 7 1976 1985 doi 10 1039 C8SC05155K PMC 6381411 PMID 30881627 Li Hongyu Valkenier Hennie Thorne Abigail G Dias Christopher M Cooper James A Kieffer Marion Busschaert Nathalie Gale Philip A Sheppard David N Davis Anthony P 2019 Anion carriers as potential treatments for cystic fibrosis transport in cystic fibrosis cells and additivity to channel targeting drugs Chemical Science 10 42 9663 9672 doi 10 1039 C9SC04242C PMC 6984391 PMID 32055336 Busschaert Nathalie Park Seong Hyun Baek Kyung Hwa Choi Yoon Pyo Park Jinhong Howe Ethan N W Hiscock Jennifer R Karagiannidis Louise E Marques Igor Felix Vitor Namkung Wan Sessler Jonathan L Gale Philip A Shin Injae July 2017 A synthetic ion transporter that disrupts autophagy and induces apoptosis by perturbing cellular chloride concentrations Nature Chemistry 9 7 667 675 Bibcode 2017NatCh 9 667B doi 10 1038 nchem 2706 PMC 5648535 PMID 28644464 Park Sang Hyun Park Seong Hyun Howe Ethan N W Hyun Ji Young Chen Li Jun Hwang Inhong Vargas Zuniga Gabriela Busschaert Nathalie Gale Philip A Sessler Jonathan L Shin Injae August 2019 Determinants of Ion Transporter Cancer Cell Death Chem 5 8 2079 2098 doi 10 1016 j chempr 2019 05 001 PMC 8009298 PMID 33791443 Howe Ethan N W Gale Philip A 10 July 2019 Fatty Acid Fueled Transmembrane Chloride Transport Journal of the American Chemical Society 141 27 10654 10660 doi 10 1021 jacs 9b02116 PMID 31244178 S2CID 195695655 Wu Xin Small Jennifer R Cataldo Alessio Withecombe Anne M Turner Peter Gale Philip A 14 October 2019 Voltage Switchable HCl Transport Enabled by Lipid Headgroup Transporter Interactions Angewandte Chemie International Edition 58 42 15142 15147 doi 10 1002 anie 201907466 PMID 31400024 S2CID 199519085 Fares Mohamed Wu Xin Ramesh Deepthi Lewis William Keller Paul A Howe Ethan N W Perez Tomas Ricardo Gale Philip A 28 September 2020 Stimuli Responsive Cycloaurated OFF ON Switchable Anion Transporters Angewandte Chemie International Edition 59 40 17614 17621 doi 10 1002 anie 202006392 hdl 2123 23683 PMID 32583552 S2CID 220059631 Clarivate Analytics Highly Cited Researchers 2018 clarivate com Archived from the original on 2019 02 20 Retrieved 2020 05 05 The Bob Hay Lectureship www rsc org Supramolecular Chemistry Award 2014 Winner www rsc org Ryoji Noyori ACES Award M G Banwell Liebig Memorial Medal W Schnick Izatt Christensen Award P A Gale Cram Lehn Pedersen Prize R Klajn Angewandte Chemie International Edition 57 38 12210 17 September 2018 doi 10 1002 anie 201809044 S2CID 52018834 Staff Profile Research September 2020 Research September 2020 Retrieved 2021 07 13 Coordination Chemistry Reviews Journal Elsevier journals elsevier com Gale Philip A Gibb Bruce C Coles Simon J Supramolecular Chemistry a href Template Cite journal html title Template Cite journal cite journal a Cite journal requires journal help Retrieved from https en wikipedia org w index php title Philip A Gale amp oldid 1124930246, wikipedia, wiki, book, books, library,
